54837-15-9Relevant academic research and scientific papers
N-(Aroyl)-N-(arylmethyloxy)-α-alanines: Selective inhibitors of aldose reductase
Nencetti, Susanna,La Motta, Concettina,Rossello, Armando,Sartini, Stefania,Nuti, Elisa,Ciccone, Lidia,Orlandini, Elisabetta
, p. 3068 - 3076 (2017/05/25)
Aldose reductase (ALR2), a NADPH-dependent reductase, is the first and rate-limiting enzyme of the polyol pathway of glucose metabolism and is implicated in the pathogenesis of secondary diabetic complications. In the last decades, this enzyme has been ta
Synthesis and antimicrobial properties of cephalosporin derivatives substituted on the C(7) nitrogen with arylmethyloxyimino or arylmethyloxyamino alkanoyl groups
Gentili, Daniela,Macchia, Marco,Menchini, Elisabetta,Nencetti, Susanna,Orlandini, Elisabetta,Rossello, Armando,Broccali, Giampietro,Limonta, Donatella
, p. 224 - 231 (2007/10/03)
Some 7-aminocephalosporanic acid (7-ACA) derivatives substituted on the C(7) nitrogen with 2-(arylmethyloxyimino)propionyl (3a-f), 2-(arylmethyloxyamino)propionyl (4a-d) and (arylmethyloxyamino)acetyl (2a-d) moieties were synthesized by reaction of the ap
α-N-HYDROXYAMINO ACID DERIVATIVES
Kolasa, Teodozyj,Sharma, Sushil K.,Miller, Marvin J.
, p. 5431 - 5440 (2007/10/02)
Reactions of organolithium reagents with glyoxylate derived oximes provided a direct route to α-N-hydroxyamino acids.The process required direct attachment of an ionizable group to the glyoxylate carbonyl to prevent competitive reactions.The procedure allowed for direct formation of the α-chiral center of the newly formed α-N-hydroxyamino acid derivative.Introduction of potential chiral auxiliaries on the oxime oxygen resulted in modest diastereoselection.In most instances, use of chiral glyoxylamides also gave low diastereoselectivity.
REACTION OF ORGANOMETALLICS WITH OXIMES. SYNTHESIS OF α-N-HYDROXY AMINO ACIDS
Kolasa, Teodozyj,Sharma, Sushil,Miller, Marvin J.
, p. 4973 - 4976 (2007/10/02)
Reaction of organolithium reagents with glyoxylate and pyruvate derived oximes provides a direct ruote for the synthesis of unusual α-N-hydroxy amino acids.
