17954-22-2 Usage
Ethyl ester derivative
1-Cyano-1,2-dihydroisoquinoline-2-carboxylic acid The compound is derived from 1-Cyano-1,2-dihydroisoquinoline-2-carboxylic acid by attaching an ethyl ester group.
Usage
Building block in pharmaceutical and agrochemical synthesis The compound serves as a starting material or intermediate for creating various pharmaceutical and agrochemical compounds.
Physical appearance
Pale yellow solid At room temperature, the compound appears as a pale yellow solid.
Solubility
Sparingly soluble in water, soluble in organic solvents The compound does not dissolve well in water but dissolves in organic solvents such as ethanol and ethyl acetate.
Application
Intermediate in active pharmaceutical ingredient production It is used as an intermediate in the production of active pharmaceutical ingredients.
Application
Research and development of new drugs The compound is also utilized in the R&D of new drugs, making it a valuable tool in medicinal chemistry and drug discovery.
Chemical structure
Valuable tool for medicinal chemistry and drug discovery The specific chemical structure of 1-Cyano-1,2-dihydroisoquinoline-2-carboxylic acid ethyl ester contributes to its importance in the field of medicinal chemistry and drug discovery.
Check Digit Verification of cas no
The CAS Registry Mumber 17954-22-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,9,5 and 4 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 17954-22:
(7*1)+(6*7)+(5*9)+(4*5)+(3*4)+(2*2)+(1*2)=132
132 % 10 = 2
So 17954-22-2 is a valid CAS Registry Number.
InChI:InChI=1/C13H12N2O2/c1-2-17-13(16)15-8-7-10-5-3-4-6-11(10)12(15)9-14/h3-8,12H,2H2,1H3
17954-22-2Relevant academic research and scientific papers
Allylation and cyanation of aza-aromatics activated by chloroformate and a catalytic amount of iodine
Yadav,Reddy,Srinivas,Sathaiah
, p. 3489 - 3492 (2007/10/03)
Allyltrimethylsilane and trimethylsilyl cyanide undergo smooth addition to N-acylated quinolines in the presence of a catalytic amount of iodine to afford 2-allyl- and 2-cyano-1,2-dihydroquinoline derivatives, respectively in good yields with high chemo- and regioselectivity. A variety of functional groups such as alkyl, alkoxy, halo, and nitro functionalities are tolerated under the reaction conditions.
REISSERT COMPOUND STUDIES LXIII: PREPARATION OF REISSERT COMPOUNDS USING DIETHYLALUMINIUM CYANIDE
Duarte, Frederick F.,Popp, Frank D.
, p. 723 - 726 (2007/10/02)
Reissert compounds and analogs were synthesized from the reaction of acid halide, heterocyclic base and diethylaluminium cyanide.This new method of Reissert compound synthesis gave yields comparable to other synthetic routes.
UTILIZATION OF ACETONE CYANOHYDRIN IN THE REISSERT REACTION
Sergovskaya, N. L.,Tsizin, Yu. S.,Chernyak, S. A.
, p. 654 - 655 (2007/10/02)
A modification of the Reissert reaction based on the utilization of acetone cyanohydrin instead of potassium cyanide is proposed.
THE USE OF 18-CROWN-6 AS PHASE TRANSFER CATALYST IN THE REISSERT REACTION
Chenevert, Robert,Lemieux, Even,Voyer, Normand
, p. 1095 - 1102 (2007/10/02)
Solid-liquid phase transfer of cyanide ion by 18-crown-6 increases the yield of the Reissert reaction and eliminates the undesirable pseudo-base formation.
