180146-30-9

Basic information

• Product Name: METHYL 3-(4-AMINOPHENYL)-2-([(TERT-BUTOXY)CARBONYL]AMINO)PROPANOATE
• Synonyms: METHYL 3-(4-AMINOPHENYL)-2-([(TERT-BUTOXY)CARBONYL]AMINO)PROPANOATE
• CAS NO: 180146-30-9
• Molecular Weight: 294.351
• Mol File: 180146-30-9.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: METHYL 3-(4-AMINOPHENYL)-2-([(TERT-BUTOXY)CARBONYL]AMINO)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-(4-AMINOPHENYL)-2-([(TERT-BUTOXY)CARBONYL]AMINO)PROPANOATE(180146-30-9)
• EPA Substance Registry System: METHYL 3-(4-AMINOPHENYL)-2-([(TERT-BUTOXY)CARBONYL]AMINO)PROPANOATE(180146-30-9)

Safety Data

• Hazardous Substances Data: 180146-30-9(Hazardous Substances Data)

Upstream product

• 172749-96-1 N-[(tert-butoxy)carbonyl]-L-cysteine methyl ester 
• 55477-80-0 methyl 2-[(tert-butoxycarbonyl)amino]acrylate 
• 540-37-4 p-aminoiodobenzene 
• 180146-29-6 2-tert-Butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 85317-52-8 methyl 2-amino-3-(4-nitrophenyl)propionate 
• 1991-83-9 4-nitrophenylalanine 

Downstream Products

• 623144-13-8 methyl 2-[(tert-butoxycarbonyl)amino]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 
• 623144-31-0 methyl 2-amino-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]propanoate 
• 623144-12-7 methyl 2-[(tert-butoxycarbonyl)amino]-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4-tetrahydro-6-quinolinyl]propanoate 

Relevant articles and documents

Cu(OTf)2-Promoted 1,4-addition of alkyl bromides to dehydroalanine

Zn/Cu(OTf)2-mediated addition of alkyl bromides to dehydroalanine (Dha) derivatives including dipeptides and tripeptides in good to high yields under an aqueous medium was developed. This protocol allows selective and biocompatible access to various amino acid units from Dha derivatives.

2,6-Quinolinyl derivatives as potent VLA-4 antagonists

A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.

Aniline derivatives possessing an inhibitory effect of nitric oxide synthase

Compounds represented by the general formula (1): ? (where R1is SR6or NR7R8, where R6is typically an alkyl group having 1-6 carbon atoms, R7is a hydrogen atom, an alkyl group having 1-6 carbon atoms or a nitro group, and R8is a hydrogen atom or an alkyl group having 1-6 carbon atoms; R2and R3are each typically a hydrogen atom or an alkyl group having 1-6 carbon atoms; R4is a hydrogen atom, an alkyl group having 1-6 carbon atoms or an amidino group of which the amine portion may be substituted by an alkyl or nitro group; R5is a hydrogen atom or an alkyl group having 1-6 carbon atoms; Y1, Y2, Y3and Y4which may be the same or different are each typically a hydrogen atom, a halogen atom or an alkoxy group having 1-6 carbon atoms; n and m are each an integer of 0 or 1), or possible stereoisomers or optically active forms of the compounds or pharmaceutically acceptable salts thereof. The compounds possess a potent nitric oxide synthase inhibiting activity and are useful as therapeutics of cerebrovascular diseases.