180624-25-3

Basic information

• Product Name: 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER;Methyl 7-Methyl-1H-indole-5-carboxylate;1H-INDOLE-5-CARBOXYLIC ACID, 7-METHYL-, METHYL ESTER
• CAS NO: 180624-25-3
• Molecular Formula: C11H11NO2
• Molecular Weight: 189.22
• Mol File: 180624-25-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 345.121°C at 760 mmHg
• Flash Point: 162.524°C
• Appearance: /
• Density: 1.213g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.624
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER(180624-25-3)
• EPA Substance Registry System: 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER(180624-25-3)

Safety Data

• Hazardous Substances Data: 180624-25-3(Hazardous Substances Data)

Usage

General Description

7-Methyl-1H-indole-5-carboxylic acid methyl ester is a chemical compound with the molecular formula C11H11NO2. It is a methyl ester derivative of 7-methyl-1H-indole-5-carboxylic acid and belongs to the indole class of organic compounds. It is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 7-METHYL-1H-INDOLE-5-CARBOXYLIC ACID METHYL ESTER has been found to exhibit potential anti-inflammatory and antimicrobial properties, making it of interest in the pharmaceutical and medical industries. Additionally, it is also used in the research and development of new drugs and organic synthesis.

InChI:InChI=1/C11H11NO2/c1-7-5-9(11(13)14-2)6-8-3-4-12-10(7)8/h3-6,12H,1-2H3

Upstream product

• 13061-96-6 dihydroxy-methyl-borane 
• 885523-35-3 methyl 7-bromo-1H-indole-5-carboxylate 
• 124-41-4 sodium methylate 
• 180624-11-7 methyl 4-amino-3-iodo-5-methyl-benzoate 
• 18595-14-7 methyl 4-amino-3-methylbenzoate 
• 2486-70-6 4-amino 3-methylbenzoic acid 
• 67-56-1 methanol 
• 3113-71-1 3-methyl-4-nitrobenzoic acid 
• 1826-67-1 vinyl magnesium bromide 
• 180624-22-0 methyl 4-amino-5-methyl-3-[2-(trimethylsilyl)ethynyl]benzoate 

Downstream Products

• 933-67-5 7-methyl-1H-indole 

Relevant articles and documents

Synthesis of diverse indole libraries on polystyrene resin - Scope and limitations of an organometallic reaction on solid supports

The synthesis of diverse substituted indole structures on solid supports is described. The immobilization of nitrobenzoic acid onto Merrifield resin and the subsequent treatment with alkenyl Grignard reagents delivered indole carboxylates bound to solid s

OXOPIPERAZINE-AZETIDINE AMIDES AND OXODIAZEPINE-AZETIDINE AMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.

Efficient reagents for the synthesis of 5-, 7-, and 5,7-substituted indoles starting from aromatic amines: Scope and limitations

Upon reaction with IPy2BF4, 4-substituted anilines give regioselectively the corresponding o-iodoanilines in nearly quantitative yield, in a process that can be carried out on a multigram scale. Palladium-catalyzed coupling of the resulting 2-iodoanilines with (trimethylsilyl)acetylene (TMSA), followed by efficient CuI-mediated nitrogen cyclization onto alkynes with concurrent elimination of the TMS substituent, allows a straightforward elaboration of 5-mono- and 5,7-disubstituted indoles from aromatic amines. This new approach to the aforementioned indoles does not requires protective groups on nitrogen at any step and can be adapted for preparing related 7-monosubstituted indoles. Moreover, examples iterating the process are given, allowing bis-annulation and sequential double annulation and resulting in synthesis of benzodipyrroles. Additionally, suitable conditions for iodination of some of the target indoles with IPy2BF4 are discussed.