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Usage

Uses

Used in Pharmaceutical Industry:
4'-METHOXY-BIPHENYL-2-CARBOXYLIC ACID is used as a starting material for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents. Its unique structure allows for versatile chemical modifications, facilitating the creation of diverse drug candidates with potential medicinal applications.
Used in Agrochemical Industry:
In the agrochemical sector, 4'-METHOXY-BIPHENYL-2-CARBOXYLIC ACID serves as a key component in the synthesis of various agrochemicals, including pesticides and herbicides. Its incorporation into these products enhances their effectiveness in controlling pests and weeds, thereby supporting agricultural productivity.
Used in Research and Development Laboratories:
4'-METHOXY-BIPHENYL-2-CARBOXYLIC ACID is utilized as a building block in research and development laboratories, where it aids in the design and synthesis of innovative drugs and materials. Its unique chemical properties make it an attractive candidate for exploring new chemical entities with potential applications in various fields.
Used in Organic Chemistry:
4'-METHOXY-BIPHENYL-2-CARBOXYLIC ACID is employed in organic chemistry for its versatile applications in the synthesis of a wide range of organic compounds. Its reactivity and functional groups enable chemists to perform various chemical reactions, leading to the formation of new molecules with diverse properties and potential uses.

Upstream product

• 67526-82-3 4'-hydroxy-1,1'-biphenyl-2-carboxylic acid 
• 74-88-4 methyl iodide 
• 17103-25-2 methyl 4'-methoxybiphenyl-2-carboxylate 
• 131-62-4 1-hydroxy-1,2-benzodioxol-3-(1H)-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 88-67-5 2-Iodobenzoic acid 
• 100-66-3 methoxybenzene 
• 16419-60-6 2-Methylphenylboronic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 858035-49-1 ethyl 4'-methoxy-[1,1'-biphenyl]-2-carboxylate 
• 92495-54-0 4'-methoxy-2-methylbiphenyl 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 56031-19-7 N-acetyl-N'-benzoyl-o-phenylenediamine 
• 696-62-8 para-iodoanisole 

Downstream Products

• 1143-62-0 3-Methoxy-6H-dibenzopyran-6-one 
• 408367-44-2 tert-Butyl 2-{6-[(tert-butoxycarbonyl)amino]-2-pyridinyl}ethyl(4-{[(4'-methoxy-1,1'-biphenyl-2-yl)carbonyl]amino}phenyl)carbamate 
• 157921-29-4 4'-Methoxy-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide 
• 1246739-37-6 10-ethyl-2-methoxy-9-phenylphenanthrene 
• 1246739-38-7 9-ethyl-2-methoxy-10-phenylphenanthrene 
• 1246739-29-6 1,2,3,4-tetraphenyl-5-(4-methoxyphenyl)naphthalene 
• 1139-83-9 urolithin B 
• 1286261-77-5 4′-methoxy-N-phenyl-[1,1′-biphenyl]-2-carboxamide 
• 1239886-89-5 3-methoxy-6-(4′-methylphenyl)phenanthridine 
• 408369-10-8 tert-butyl 4-{[(4'-methoxy-1,1'-biphenyl-2-yl)carbonyl]amino}phenyl[2-(2-methyl-1,3-thiazol-4-yl)ethyl]carbamate 
• 408367-68-0 tert-Butyl 2-{2-[(tert-butoxycarbonyl)amino]-1,3-thiazol-4-yl}ethyl(4-{[(4'-methoxy-1,1'-biphenyl-2-yl)carbonyl]amino}phenyl)carbamate 
• 57353-93-2 4-(4-methoxyphenyl)-1,2-dihydrophthalazin-1-one 
• 1027504-49-9 5-(4-Methoxy-phenyl)-4H-isoquinoline-3,3-dicarboxylic acid diethyl ester 
• 1026003-67-7 5-(4-Methoxy-phenyl)-1,4-dihydro-2H-isoquinoline-3,3-dicarboxylic acid diethyl ester 

Relevant academic research and scientific papers

Nickel-Catalyzed Ortho-Arylation of Unactivated (Hetero)aryl C-H Bonds with Arylsilanes Using a Removable Auxiliary

Ni(II)-catalyzed ortho-arylation of aromatic and heteroaromatic carboxamides with triethoxy(aryl)silanes assisted by a removable bidentate auxiliary is reported. This transformation features a broad substrate scope, good functional group tolerance, and co

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

Transition-Metal-Free Synthesis of Phenanthridinones through Visible-Light-Driven Oxidative C–H Amidation

The treatment of N-aryl biphenylcarboxamide, 1-chloroanthraquinone (1-Cl-AQN) catalyst, and K2CO3 in CHCl3 under visible light irradiation affords phenanthridinone via radical cyclization. This reaction proceeds under transition-metal-free condition, room temperature, and direct C–H amidation. Mechanistic studies indicate that amidyl radical generation proceeds by visible light induced proton coupled electron transfer (PCET) from N–H bond of the amide.

Visible-Light-Induced Arene C(sp 2)-H Lactonization Promoted by DDQ and tert -Butyl Nitrite

A visible-light photocatalytic aerobic oxidative lactonization of arene C(sp 2)-H bonds proceeds in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and tert -butyl nitrite (TBN). Under the optimized conditions, a range of 2-arylbenzoic acids is converted into the corresponding benzocoumarin derivatives in moderate to excellent yields. This method is characterized by its atom economy, mild reaction conditions, the use of a green oxidant and metal-free catalysis.

Facile preparation of 3,4-benzocoumarins from 2-arylbenzoic acids with NCS and NAI

– Treatment of 2-arylbenzoic acids with N-chlorosuccinimide (NCS) and NaI at 70 °C under fluorescent lighting condition gave the corresponding 3,4-benzocoumarins in good yields under transition-metal-free condition. It was found that the reactivity of NCS

Vitamin Catalysis: Direct, Photocatalytic Synthesis of Benzocoumarins via (-)-Riboflavin-Mediated Electron Transfer

An operationally simple protocol is disclosed to facilitate entry to benzo-3,4-coumarins directly from biaryl carboxylic acids without the need for substrate prefunctionalization. Complementary to classic lactonization strategies, this disconnection relies on the oxidation competence of photoactivated (-)-riboflavin (vitamin B2) to generate the heterocyclic core via photoinduced single electron transfer. Collectively, the inexpensive nature of the catalyst, ease of execution, and absence of external metal additives are a convincing endorsement for the incorporation of simple vitamins in contemporary catalysis.

Oxidant-Free C(sp2)-H Functionalization/C-O Bond Formation: A Kolbe Oxidative Cyclization Process

An anodic oxidation/cyclization of 2-arylbenzoic acids for the synthesis of dibenzopyranones has been developed. The reaction proceeds at room temperature with no oxidant or electrolyte required and exhibits a high atom economy with H2 being th

Palladium-Catalyzed, N-(2-Aminophenyl)acetamide-Assisted Ortho-Arylation of Substituted Benzamides: Application to the Synthesis of Urolithins B, M6, and M7

Pd-catalyzed, selective, monoarylation of ortho-C-H bonds of various benzamides with aryl/heteroaryl iodides has been realized using N-(2-aminophenyl)acetamide (APA) as a new bidentate directing group for the first time. The reaction was tolerant of a wid

Ruthenium(II)-catalyzed C-H functionalizations on benzoic acids with aryl, alkenyl and alkynyl halides by weak-: O -coordination

C-H arylations of weakly coordinating benzoic acids were achieved by versatile ruthenium(ii) catalysis with ample substrate scope. Thus, user-friendly ruthenium(ii) biscarboxylate complexes modified with tricyclohexylphosphine enabled C-H functionalizations with aryl electrophiles. The unique versatility of the ruthenium(ii) catalysis manifold was reflected by facilitating effective C-H activations with aryl, alkenyl and alkynyl halides.

Room-temperature cobalt-catalyzed arylation of aromatic acids: overriding the ortho-selectivity via the oxidative assembly of carboxylate and aryl titanate reagents using oxygen

A room temperature phosphine or NHC ligand-free cobalt-catalyzed arylation of (hetero)aromatic acids has been developed. It involves an oxidative cross-coupling between carboxylate and aryl titanate reagents using oxygen as an oxidant, and the arylation at the position ortho, meta and para to the carboxylic acid group could all be achieved. As application, various (hetero)aromatic acids including xenalipin, tafamidis and the key intermediate for a cardioprotective compound have been efficiently synthesized.