18211-41-1

Basic information

• Product Name: 4'-NITRO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID
• Synonyms: 4'-NITRO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;4'-nitrobiphenyl-2-carboxylic acid;2-(4-Nitrophenyl)benzoic acid
• CAS NO: 18211-41-1
• Molecular Formula: C₁₃H₉NO₄
• Molecular Weight: 243.21
• Mol File: 18211-41-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 228-230°C
• Boiling Point: 420.4°Cat760mmHg
• Flash Point: 180.5°C
• Appearance: /
• Density: 1.358g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4'-NITRO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-NITRO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(18211-41-1)
• EPA Substance Registry System: 4'-NITRO[1,1'-BIPHENYL]-2-CARBOXYLIC ACID(18211-41-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 18211-41-1(Hazardous Substances Data)

Usage

Uses

4''-Nitro-[1,1''-biphenyl]-2-carboxylic Acid is a useful compound for study of general and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes.

Upstream product

• 37051-42-6 bis-(2-carboxy-benzoyl)-peroxide 
• 98-95-3 nitrobenzene 
• 24067-17-2 4-nitrophenylboronic acid 
• 17103-24-1 methyl 4'-nitro-1,1'-biphenyl-2-carboxylate 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 586-78-7 para-nitrophenyl bromide 
• 16419-60-6 2-Methylphenylboronic acid 
• 149105-19-1 2-carboxyphenylboronic acid 
• 947-84-2 2-Biphenylcarboxylic acid 
• 2005-10-9 6H-benzo[c]chromen-6-one 
• 33350-73-1 2-methyl-4'-nitro-1,1'-biphenyl 

Downstream Products

• 25829-61-2 4'-aminobiphenyl-2-carboxylic acid 
• 101035-98-7 4',4'''-azoxy-bis-biphenyl-2-carboxylic acid 
• 67526-82-3 4'-hydroxy-1,1'-biphenyl-2-carboxylic acid 
• 6638-64-8 7-nitro-3,4-benzocoumarin 
• 27370-21-4 6-({4'-[6-(4-Chloro-benzyloxycarbonylamino)-hexanoylamino]-biphenyl-2-carbonyl}-amino)-hexanoic acid 
• 18110-71-9 4'-methoxybiphenyl-2-carboxylic acid 
• 1143-62-0 3-Methoxy-6H-dibenzopyran-6-one 
• 157921-26-1 4'-Nitro-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide 
• 157921-35-2 4'-Amino-biphenyl-2-carboxylic acid [4-(2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-amide 

Relevant articles and documents

General and practical carboxyl-group-directed remote C-H oxygenation reactions of arenes

Two methods for remote aromatic C-H oxygenation reactions, have been developed. Method1, the Cu-catalyzed oxygenation reaction, is highly efficient for cyclization of electron-neutral and electron-rich biaryl carboxylic acids into 3,4-benzocoumarins. Method2, the K2S2O 8-mediated oxygenation reaction, is more general and practical for cyclization of substrates with electron-donating and -withdrawing groups (see scheme). Copyright

Quantum-chemical substantiation of the reactivity and regioselectivity of nitration of biphenyl derivatives

Quantum-chemical calculations were used to substantiate the reactivity and regioselectivity of nitration of benzene, biphenyl, and carboxy-substituted biphenyls.

Construction of a family of biphenyl combinatorial libraries: Structure- activity studies utilizing libraries of mixtures

A set of biphenyl aminoacid building blocks has been synthesized. These were used to construct partially-peptidic combinatorial libraries as equimolar multi-component samples. Activity of members of this library as vitronectin receptor antagonists is described, together with SAR studies of the most active members. These studies illustrate several important features of combinatorial libraries.