1817-95-4

Usage

Uses

Used in Food Industry:
4-Methoxy-1,3-benzodioxole is used as a flavoring agent for its sweet, floral scent, enhancing the taste and aroma of various food products.
Used in Pharmaceutical Industry:
4-Methoxy-1,3-benzodioxole serves as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new drugs and medications.
Used in Fragrance Industry:
As a key intermediate, 4-Methoxy-1,3-benzodioxole is utilized in the creation of various fragrances, adding depth and complexity to scents in perfumes, cosmetics, and other scented products.
Used in Pest Control Industry:
Leveraging its insecticidal properties, 4-Methoxy-1,3-benzodioxole is employed in insecticides and pest control products to effectively manage and eliminate pests.
Safety Precautions:
It is crucial to handle 4-Methoxy-1,3-benzodioxole with care, as it can cause skin and eye irritation. Additionally, inhalation of large quantities may lead to respiratory irritation. Proper safety measures should be taken to minimize potential health risks during its use and handling.

Upstream product

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• 934-00-9 3-methocycatechol 
• 75-11-6 diiodomethane 
• 74-95-3 1,1-dibromomethane 
• 74-97-5 chlorobromomethane 
• 69393-72-2 2H-benzo[d][1,3]dioxolan-4-ol 
• 77-78-1 dimethyl sulfate 
• 75-09-2 dichloromethane 

Downstream Products

• 5779-99-7 4-methoxybenzo[d][1,3]dioxole-5-carbaldehyde 
• 23731-55-7 4-methoxy-2,3-methylenedioxy-benzaldehyde 
• 61535-22-6 1-bromo-4-methoxy-2,3-methylenedioxybenzene 
• 118871-61-7 5-bromo-4-methoxy-benzo[1,3]dioxole 
• 934-00-9 3-methocycatechol 
• 76965-90-7 7-benzyloxy-2'-methoxy-3',4'-methylenedioxyisoflavone 
• 634-36-6 1,2,3-trimethoxybenzene 
• 477-82-7 evoxanthine 
• 484-32-2 2-methoxy-3,4-methylenedioxybenzoic acid 
• 92830-79-0 (methoxy-2 methylenedioxy-3,4 benzyl)-4 <(dimethoxy-3',5' hydroxy-4' phenyl) hydroxymethyl>-3 dihydro-3H-furannone-2 
• 78994-22-6 (methoxy-2 methylenedioxy-3,4 benzyl)-4 <(trimethoxy-3',4',5' phenyl) hydroxymethyl>-3 dihydro-3H-furannone-2 
• 82299-44-3 ether methylique de la (+/-) iso α-peltatine 
• 82314-37-2 (5aS,8aR)-5-Hydroxy-5-(4-hydroxy-3,5-dimethoxy-phenyl)-10-methoxy-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 
• 82314-36-1 (5aS,8aR)-5-Hydroxy-10-methoxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 

Relevant academic research and scientific papers

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity

Based on the conformation of the α-methyl chalcone TUB091 in its complex with tubulin, a series of conformational mimetics have been designed and synthesized where the methyl group of the chalcone has been fused to phenyl ring B resulting in 1,2,3,4-tetrahydronaphthalen-2-yl aryl ketones. Among the synthesized compounds, the 5-amino-6-methoxy derivative, with a similar substitution pattern to that of TUB091, showed antiproliferative activity around 20 nM against tumor and endothelial cells. Tubulin binding experiments confirmed its binding to tubulin at the colchicine site with a Kb of 2.4 × 106 M?1 resulting in the inhibition of the in vitro assembly of purified tubulin. Moreover, based on the recently reported complex of combretastatin A4 (CA4) with tubulin, a comparative analysis of the binding mode of CA4 and the α-methyl chalcone to tubulin has been performed.

A High-Yield Method for the Methylenation of o-Dihydroxyaromatic Compounds: Synthesis of Methylenedioxycoumarins

Reaction of o-dihydroxycoumarins and catechols with sodium hydride in hexamethylphosphoric triamide and dihalomethane provides the corresponding methylenedioxy compounds under mild conditions and in excellent yields.

Synthesis of Cotarnin Iodide

Starting from 4-methoxy-1,3-benzodioxol-5-carbaldehyde (croweacin aldehyde, 3) a six-step synthesis of cotarnin iodide (9, 67percent total yield) is described. - Keywords.Croweacinaldehyde; Isoquinoline; Cotarnin iodide.

Ab Initio and 17O NMR Study of Aromatic Compounds with Dicoordinate Oxygen Atoms. 1. Methoxy- and (Methylenedioxy)benzene Derivatives

17O NMR data at natural abundance in toluene-d8 at 74 deg C were obtained for aromatic compounds containing methoxy and methylenedioxy groups as side-chains substituents. 17O chemical shifts of this series of compounds are significantly influenced by both electronic and steric effects.Ortho electronic and steric subtituent chemical shift effects for methoxy and methylenedioxy groups were estimated.Ab inito calculations at the 4-31G level were used to determine geometries of the compounds to gain insight into the structural aspects of these compounds.A correlation between the calculated bond orders, P(CAr-O), and the 17O chemical shift was found.

TRICYCLIC INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND USES THEREOF

The present application relates to compounds of Formula I (I) or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, to compositions comprising these compounds or pharmaceutically acceptable salts, solvates and/or prodrugs thereof, and various uses in the treatment of diseases, disorders or conditions that are treatable by inhibiting interactions with BCL6 BTB, such as cancer.

A re-examination of the methylenation reaction

A re-examination of the methylenation reaction of 1-hydroxy-2-mercapto-, 1,2-dihydroxy- and 1,2-dimercapto-substituted benzenes by bromochloromethane with cesium carbonate shows that these substrates give mixtures of five- and ten-membered benzocondensed heterocyclic compounds and in some cases even dibenzodioxines.

PREPARATION OF 2-METHOXY-3,4-METHYLENEDIOXYBENZALDEHYDE (CROWEACIN ALDEHYDE) FROM PYROGALLOL

2-Methoxy-3,4-methylenedioxybenzaldehyde (croweacin aldehyde) of high purity was prepared in 55percent overall yield from pyrogallol.

The Chemistry of 2H-3,1-Benzoxazine-2,4(1H)-dione (Isatoic Anhydride). 21. A Mild Process For The Preparation of 10-Alkyl-9-acridanones And It's Application To The Synthesis of Acridone Alkaloids

10-Substituted-9-acridanones are readily prepared by the reaction of the corresponding isatoic anhydride with the lithium enolate of 2-cyclohexen-1-one.The initially formed product, the 1,2-dihydroacridone need not be purified but can be aromatized directly with DDQ to the desired acridone.This methodology is applicable to the synthesis of acridone natural products.Two alkaloids, 1,2,3-trimethoxy-10-methylacridone (9) and evoxanthine (10), were prepared from 4,5,6-trimethoxy-N-methylisatoic anhydride and 6-methoxy-4,5-methylenedioxy-N-methylisatoic anhydride respectively.In these trioxygenated systems, palladium-on-charcoal must be used to aromatize the penultimate intermediate.