181872-19-5

Upstream product

• 88056-92-2 (-)-2-cyano-6-phenyloxazolopiperidine 
• 591-51-5 phenyllithium 

Downstream Products

• 181872-28-6 N-{(R)-[(2S)-1-((1R)-2-hydroxy-1-phenylethyl)piperidin-2-yl]phenylmethyl}benzamide 
• 181872-29-7 N-[(R)-phenyl((2S)-piperidin-2-yl)methyl]benzamide 
• 181872-24-2 (2R)-2-{(2S)-2-[(R)-(1-aminophenyl)methyl]piperidin-1-yl}-2-phenylethanol 
• 511521-69-0 [(7S)-benzyl-(2R)-phenyl-azepan-(3S)-yl]-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-amine 
• 511521-68-9 [2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-((7S)-isobutyl-(2R)-phenyl-azepan-(3S)-yl)-amine 
• 511521-67-8 [2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-((7R)-methyl-(2R)-phenyl-azepan-(3S)-yl)-amine 
• 511521-58-7 (1S,5R)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-(7R)-phenyl-6,8-diazabicyclo[3.2.1]octane 
• 511521-54-3 (1S,5S)-8-[2-(tert-butyl-dimethyl-silanyloxy)-(1R)-phenyl-ethyl]-7-phenyl-6,8-diazabicyclo[3.2.1]oct-6-ene 
• 264255-44-9 (R)-2-Phenyl-2-((2R,3S)-2-phenyl-azepan-3-ylamino)-ethanol 
• 181872-21-9 (1S,4R,9aS)-1,4-Diphenyl-octahydro-pyrido[2,1-c][1,4]oxazin-1-ylamine 

Relevant academic research and scientific papers

Substitution and stereochemical effects in the reactions of combined aminonitrile-oxazolidines with a Grignard reagent

A study of the reaction of phenyl magnesium bromide with various N- (cyanomethyl)oxazolidines showed that product formation (essentially 3- imidazolines and 2-aminomorpholines) is highly sensitive to the substitution pattern and stereochemistry, and appea

Practical asymmetric synthesis of 1,2-diamines in the 3-aminoazepane series

A simple and versatile method for the enantio- and diastereoselective synthesis of mono- or disubstituted 3-aminoazepanes is described. The key step involves a highly regio- and diastereoselective tandem ring-enlargement/alkylation or reduction process. T

Asymmetric synthesis. 39. Synthesis of 2-(1-aminoalkyl)piperidines via 2-cyano-6-phenyl oxazolopiperidine

The asymmetric synthesis of a series of 2-(1-aminoalkyl) piperidines using (-)-2-cyano-6-phenyloxazolopiperidine 1 is described. LiAlH4 reduction of 1 followed by hydrogenolysis led to the diamine 3. The same strategy applied to C-2-methylated