1820-59-3Relevant articles and documents
Method for nitrating aromatic compound by using nitrate under the action of auxiliary agent
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Paragraph 0067; 0068, (2018/09/11)
The invention discloses a method for nitrating an aromatic compound by using a nitrate under the action of an auxiliary agent, and provides an aromatic nitro compound preparation method, which comprises: in the presence of an external action and an auxiliary agent, carrying out a nitrating reaction on an aromatic compound and a metal nitrate or a hydrate thereof to obtain the aromatic nitro compound, wherein the external action can cause the physical and/or chemical property change of a substance, the auxiliary agent is a substance having water absorbing ability, the external action can be mechanical force or heating, and the mechanical force can be any one selected from compression, shearing, impacting, friction, stretching, bending and vibration. According to the present invention, the method does not require any solvents so as to avoid the generation of the waste liquid; the acidic substance is not used, such that the treatment is simple after the reaction is completed, and the equipment is not damaged; the added auxiliary agent can be theoretically recycled; and the method has extremely high conversion rate and extremely high selectivity, and can be used for the nitration of conventional aromatic compounds.
Synthesis of indoles via palladium[0]-mediated ullmann cross-coupling of o-halonitroarenes with α-halo-enones or -enals
Banwell, Martin G.,Kelly, Brian D.,Kokas, Okanya J.,Lupton, David W.
, p. 2497 - 2500 (2007/10/03)
(Matrix presented) Palladium[0]-mediated Ullmann cross-coupling of o-halonitrobenzene (1) and various related nitroarenes with a range of α-halo-enones (e.g., 2) or -enals readily affords the expected α-arylenones, e.g., 3, or -enals, which are converted into the corresponding indoles, e.g., 4, on reaction with dihydrogen in the presence of Pd on C.
SYNTHESIS OF 5-NITRO-5-(4-NITROPHENYL)-1,3-TETRAHYDROOXAZINES AND 5-NITRO-5-(1-ARYLOXYMETHYL)-1,3-TETRAHYDROOXAZINES, AND HEXAHYDROPYRIMIDINES IN NUCLEOPHILIC AROMATIC SUBSTITUTION
Galeeva, A. G.,Trifonova, V. N.,Kasatkina, A. A.,Zorin, V. V.,Rakhmankulov, D. L.
, p. 1019 - 1021 (2007/10/02)
The lithium salts of 3-alkyl-5-nitro-1,3-tetrahydrooxazines and the lithium alcoholates of 5-hydroxymethyl-3-methyl-5-nitro-1,3-tetrahydrooxazine and 5-hydroxymethyl-1,3-dimethyl-5-nitrohexahydropyrimidine enter into nucleophilic aromatic substituent with p-dinitrobenzene and 2,4-dinitrobromobenzene to form 3-alkyl-5-nitro-5-(4-nitrophenyl)-1,3-tetrahydrooxazines, 3-methyl-5-nitro-5-(4-nitrophenyloxymethyl)-1,3-tetrahydrooxazine, and 1,3-dimethyl-5-nitro-5-(aryloxymethyl)hexahydropyrimidines.