18231-00-0Relevant academic research and scientific papers
NEW GLYCOLIPIDS AND USE THEREOF AS SK3 ION CHANNEL MODULATORS
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Page/Page column 40-41, (2022/01/24)
The present invention relates to new glycolipids derivatives of Formula (I) and their use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels. The present invention further relates to pharmaceutical compositions comprising compounds of Formula (I) for use in the treatment of diseases related with a deregulation of the expression and/or activity of SK3 ion channels.
Thio-ether functionalized glycolipid amphiphilic compounds reveal a potent activator of SK3 channel with vasorelaxation effect
Sevrain, Charlotte M.,Fontaine, Delphine,Bauduin, Alicia,Guéguinou, Maxime,Zhang, Bei Li,Chant?me, Aurélie,Mahéo, Karine,Pasqualin, C?me,Maupoil, Véronique,Couthon, Hélène,Vandier, Christophe,Jaffrès, Paul-Alain
, p. 2753 - 2766 (2021/04/07)
The modulation of SK3 ion channels can be efficiently and selectively achieved by using the amphiphilic compound Ohmline (a glyco-glycero-ether-lipid). We report herein a series of Ohmline analogues featuring the replacement of one ether function by a thi
Flexible metathesis-based approaches to highly functionalised furans and pyrroles
Donohoe, Timothy J.,Kershaw, Neil M.,Orr, Allan J.,Wheelhouse, Katherine M.P.,Fishlock, Lisa?P.,Lacy, Adam R.,Bingham, Matilda,Procopiou, Panayiotis A.
, p. 809 - 820 (2008/09/16)
A range of differentially functionalised furans and pyrroles have been synthesised in short order by the judicious use of a ring-closing metathesis/aromatisation strategy. Two contrasting approaches are described exploiting a palladium-catalysed union of
Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM
Lu, Kui,Huang, Mengwei,Xiang, Zheng,Liu, Yongxiang,Chen, Jiahua,Yang, Zhen
, p. 1193 - 1196 (2007/10/03)
A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally divers
Macrocyclic kinase inhibitors
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Page/Page column 78, (2010/02/14)
Compounds having the formula are useful for inhibiting protein kinases. Also disclosed are methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.
THIA-ACYLIMINIUM CYCLISATIONS. SYNTHESIS OF FIVE-MEMBERED RINGS AND MACROCYCLES
Hamersma, J. A. M.,Nossin, P. M. M.,Speckamp, W. N.
, p. 1999 - 2006 (2007/10/02)
Cyclisations of carbinollactams 1b-3b afford macrocycles 4-6 in good yield by the intermediacy of N-acyliminium species.A similar process applied to lactams 21b-25b affords the pyrrolizidine type compounds 26-35 through consecutive azonium-Cope rearrangem
