18231-99-7

Upstream product

• 23030-43-5 2,5-dihydroxy-1-iodobenzene 
• 583-69-7 2-bromobenzene-1,4-diol 
• 37407-24-2 4-amino-3-(methylthio)phenol 
• 123-31-9 hydroquinone 
• 25245-35-6 1-iodo-2,4-dimethoxybenzene 
• 2570-42-5 2-(methylthio)-1,4-dimethoxybenzene 
• 106-51-4 p-benzoquinone 
• 2889-61-4 2-mercaptobenzene-1,4-diol 
• 74-88-4 methyl iodide 

Downstream Products

• 18232-06-9 2-methylthio-p-benzoquinone 

Relevant academic research and scientific papers

A visible-light photocatalytic thiolation of aryl, heteroaryl and vinyl iodides

The general catalytic synthesis of aryl and vinyl thioethers from readily available halides remains a challenge. Herein we report a unified method for the thiolation of aryl and vinyl iodides with dialkyl disulfides using visible light photoredox catalysis. A range of thioether products bearing diverse functional groups can be accessed in high yield and with excellent chemoselectivity. We demonstrate the versatility of this method through the expedient synthesis of a family of thioether-rich natural products. A detailed investigation of the photocatalytic mechanism is presented from both steady-state and time-resolved luminescent quenching as well as transient absorption spectroscopy experiments.

Synthesis and antioxidative activity of S-substituted 2-mercapto-1,4- dihydroxybenzenes

S-Substituted 2-mercapto-1,4-dihydroxybenzenes were prepared, and their antioxidative activity in autooxidation of cumene and in the reactions with cumylperoxy radicals and cumyl hydroperoxide was studied.

Process for phenol alkylthiolation and its application to the synthesis of 4-acyl-2-alkylthiophenols

The invention relates to the preparation of alkylthiophenols by reaction of a dialkyl disulphide with a phenol. In the process according to the invention, the reaction is carried out in the presence of aluminum chloride or of ferric chloride in a solvent of the alkylbenzene type or, soley in the case of methylthiolation, in an excess of dimethyl disulphide. This process makes it possible, in particular to obtain, with a selectivity and in a yield which are excellent, 2-alkylthiophenols which may then be converted into 4-acyl-2-alkylthiophenols by means of a reaction at a temperature ranging from 40° to 100° C. with a complex BF3 :2RCOOH where R denotes an alkyl or propenyl radical, in a proportion of 10 to 15 moles of complex per mole of 2-alkylthiophenol.

THE GENERATION OF C,O,O-TRILITHIATED DERIVATIVES OF DIHYDRIC PHENOLS

Halogenated dihydric phenols (hydroquinones and resorcinols) undergo halogen metal exchange with nBuLi/TMEDA/THF or ether (inverse addition) under sonication, thereby generating a C,O,O-trilithiated species which can be trapped with electrophiles.