2570-42-5

Basic information

• Product Name: 2,5-DIMETHOXYBENZENETHIOL
• Synonyms: 1,4-dimethoxy-2-methylsulfanylbenzene
• CAS NO: 2570-42-5
• Molecular Formula: C₉H₁₂O₂S
• Molecular Weight: 184.26
• Mol File: 2570-42-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 264.4°Cat760mmHg
• Flash Point: 113.7°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.0159mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 2,5-DIMETHOXYBENZENETHIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DIMETHOXYBENZENETHIOL(2570-42-5)
• EPA Substance Registry System: 2,5-DIMETHOXYBENZENETHIOL(2570-42-5)

Safety Data

• Hazardous Substances Data: 2570-42-5(Hazardous Substances Data)

Usage

General Description

2,5-DIMETHOXYBENZENETHIOL, also known as veratrole thiol, is a chemical compound with the formula C9H10O2S. It is a colorless to pale yellow liquid with a strong, unpleasant odor. 2,5-DIMETHOXYBENZENETHIOL is used primarily in the manufacture of flavors and fragrances. It is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. The compound is known for its strong odor, which makes it useful as a scent additive in perfumes and other personal care products. Additionally, 2,5-DIMETHOXYBENZENETHIOL is used in the production of food flavorings and as a chemical intermediate in the synthesis of various organic compounds.

InChI:InChI=1/C9H12O2S/c1-10-8-5-4-7(12-3)6-9(8)11-2/h4-6H,1-3H3

Upstream product

• 624-92-0 Dimethyldisulphide 
• 25245-35-6 1-iodo-2,4-dimethoxybenzene 
• 4991-65-5 tioxolone 
• 74-88-4 methyl iodide 
• 150-78-7 1,4-dimethoxybezene 
• 1483-27-8 2,5-dimethoxythiophenol 
• 2889-61-4 2-mercaptobenzene-1,4-diol 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 61638-04-8 2,5-dimethoxy-4-methylsulfidebenzaldehyde 
• 849919-81-9 N-formyl-1-(2,5-dimethoxy-4-methylthiophenyl)-2-aminopropane 
• 69294-31-1 1-(2,5-dimethoxy-4-methylthiophenyl)-2-nitro-1-butene 
• 849919-85-3 N-formyl-1-(2,5-dimethoxy-4-methylthiophenyl)-2-aminobutane 
• 61638-05-9 1-(2,5-dimethoxy-4-methylthiophenyl)-2-nitro-1-propene 
• 61638-07-1 2,5-dimethoxy-4-(methylthio)amphetamine 
• 756766-56-0 2-amino-1-(2,5-dimethoxy-4-methylthiophenyl)butane 
• 38417-33-3 2,5-Dimethoxyphenylmethylsulfoxid 
• 61638-09-3 2,5-dimethoxy-4-methylthiophenethylamine 
• 61638-06-0 1,4-Dimethoxy-2-methylsulfanyl-5-((Z)-2-nitro-vinyl)-benzene 
• 18231-99-7 1,4-dihydroxy-2-(methylthio)benzene 
• 93725-01-0 <2.5-Dimethoxy-4-methylmercapto-phenylimino>-bernsteinsaeurediaethylester 

Relevant articles and documents

Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl shift condition using 1,4-dioxane w

Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling

A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-α methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC50 in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure-activity relationship study for MAO-A inhibition was performed on the series using comparative molecular field analysis (CoMFA). The resulting model gave a cross-validated q2 of 0.72 and showed that in this series of compounds steric properties of the substituents were more important than electrostatic effects. Molecular modeling based on the recently published crystal structure of inhibitor-bound MAO-A provided detailed evidence for specific interactions of the ligands with the enzyme, supported by previous references and consistent with results from the CoMFA. On the basis of these results, structural determinants for selectivity of substituted amphetamines for MAO-A are discussed.

Sulfur analogs of psychotomimetic amines

The syntheses and physical properties are described for 2,5 dimethoxy 4 methylthiophenylethylamine and 2,5 dimethoxy 4 methylthiophenylisopropylamine. The latter compound is the sulfur analog of the psychotomimetic phenylisopropylamines 2,4,5 trimethoxyphenylisopropylamine and 2,5 dimethoxy 4 methylphenylisopropylamine wherein the methylthio group replaces a methoxy group or a methyl group, respectively. This compound is predicted to be about 30 times as active as mescaline.