2570-42-5

Usage

Uses

Used in Flavor and Fragrance Industry:
2,5-DIMETHOXYBENZENETHIOL is used as a scent additive for its strong odor, making it suitable for enhancing the fragrance profiles in perfumes and other personal care products.
Used in Pharmaceutical Industry:
2,5-DIMETHOXYBENZENETHIOL serves as an intermediate in the synthesis of pharmaceuticals, contributing to the development of new medications and therapeutic agents.
Used in Food Industry:
In the food industry, 2,5-DIMETHOXYBENZENETHIOL is utilized in the production of food flavorings, adding unique taste and aroma characteristics to various food products.
Used in Organic Synthesis:
2,5-DIMETHOXYBENZENETHIOL is employed as a chemical intermediate in the synthesis of various organic compounds, playing a crucial role in the creation of a wide range of chemical products.

InChI:InChI=1/C9H12O2S/c1-10-8-5-4-7(12-3)6-9(8)11-2/h4-6H,1-3H3

Upstream product

• 1483-27-8 2,5-dimethoxythiophenol 
• 77-78-1 dimethyl sulfate 
• 2889-61-4 2-mercaptobenzene-1,4-diol 
• 74-88-4 methyl iodide 
• 624-92-0 Dimethyldisulphide 
• 25245-35-6 1-iodo-2,4-dimethoxybenzene 
• 4991-65-5 tioxolone 
• 150-78-7 1,4-dimethoxybezene 

Downstream Products

• 38417-33-3 2,5-Dimethoxyphenylmethylsulfoxid 
• 61638-04-8 2,5-dimethoxy-4-methylsulfidebenzaldehyde 
• 18231-99-7 1,4-dihydroxy-2-(methylthio)benzene 
• 93725-01-0 <2.5-Dimethoxy-4-methylmercapto-phenylimino>-bernsteinsaeurediaethylester 
• 870961-59-4 2,5-dimethoxy-4-methylsulfanyl-phenylamine 
• 61638-09-3 2,5-dimethoxy-4-methylthiophenethylamine 
• 61638-06-0 1,4-Dimethoxy-2-methylsulfanyl-5-((Z)-2-nitro-vinyl)-benzene 
• 756766-56-0 2-amino-1-(2,5-dimethoxy-4-methylthiophenyl)butane 
• 61638-07-1 2,5-dimethoxy-4-(methylthio)amphetamine 
• 61638-05-9 1-(2,5-dimethoxy-4-methylthiophenyl)-2-nitro-1-propene 
• 849919-85-3 N-formyl-1-(2,5-dimethoxy-4-methylthiophenyl)-2-aminobutane 
• 69294-31-1 1-(2,5-dimethoxy-4-methylthiophenyl)-2-nitro-1-butene 
• 849919-81-9 N-formyl-1-(2,5-dimethoxy-4-methylthiophenyl)-2-aminopropane 

Relevant academic research and scientific papers

Accelerated Fmoc solid-phase synthesis of peptides with aggregation-disrupting backbones

In this work, we describe an accelerated solid-phase synthetic protocol for ordinary or difficult peptides involving air-bath heating and amide protection. For the Hmsb-based backbone amide protection, an optimized acyl shift condition using 1,4-dioxane w

A visible-light photocatalytic thiolation of aryl, heteroaryl and vinyl iodides

The general catalytic synthesis of aryl and vinyl thioethers from readily available halides remains a challenge. Herein we report a unified method for the thiolation of aryl and vinyl iodides with dialkyl disulfides using visible light photoredox catalysis. A range of thioether products bearing diverse functional groups can be accessed in high yield and with excellent chemoselectivity. We demonstrate the versatility of this method through the expedient synthesis of a family of thioether-rich natural products. A detailed investigation of the photocatalytic mechanism is presented from both steady-state and time-resolved luminescent quenching as well as transient absorption spectroscopy experiments.

Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling

A series of phenethylamine derivatives with various ring substituents and with or without N-methyl and/or C-α methyl or ethyl groups was synthesized and assayed for their ability reversibly to inhibit monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). Several compounds showed potent and selective MAO-A inhibitory activity (IC50 in the submicromolar range) but none showed appreciable activity toward MAO-B. A three-dimensional quantitative structure-activity relationship study for MAO-A inhibition was performed on the series using comparative molecular field analysis (CoMFA). The resulting model gave a cross-validated q2 of 0.72 and showed that in this series of compounds steric properties of the substituents were more important than electrostatic effects. Molecular modeling based on the recently published crystal structure of inhibitor-bound MAO-A provided detailed evidence for specific interactions of the ligands with the enzyme, supported by previous references and consistent with results from the CoMFA. On the basis of these results, structural determinants for selectivity of substituted amphetamines for MAO-A are discussed.

Monomethylthio analogues of 1-(2,4,5-trimethoxyphenyl)-2-aminopropane

Regiospecific syntheses of the three monomethylthio analogues of 1-(2,4,5- trimethoxyphenyl)-2-aminopropane are described. The three isomeric amines were evaluated for potential psychotomimetic potency using the rabbit hyperthermia assay. Enantiomeric com

Sulfur analogs of psychotomimetic amines

The syntheses and physical properties are described for 2,5 dimethoxy 4 methylthiophenylethylamine and 2,5 dimethoxy 4 methylthiophenylisopropylamine. The latter compound is the sulfur analog of the psychotomimetic phenylisopropylamines 2,4,5 trimethoxyphenylisopropylamine and 2,5 dimethoxy 4 methylphenylisopropylamine wherein the methylthio group replaces a methoxy group or a methyl group, respectively. This compound is predicted to be about 30 times as active as mescaline.