182319-85-3

Upstream product

• 100-39-0 benzyl bromide 
• 161315-45-3 N-[4-methoxybenzenesulfonyl]-(D)-valine 
• 640-68-6 D-Val-OH 
• 123-91-1 1,4-dioxane 
• 98-68-0 4-methoxy-phenyl-sulphonyl chloride 

Downstream Products

• 279254-55-6 N-Hydroxy-2(R)-[(4-methoxycarbonylbenzyl)-(4-methoxybenzenesulfonyl)amino]-3-methylbutyramide 
• 279255-91-3 2(R)-[(N-tert-butoxy-carbonylindol-5-ylmethyl)-(4-methoxybenzenesulfonyl)amino]-3-methylbutyric acid benzyl ester 
• 182319-91-1 (R)-2-[but-3-enyl (4-methoxybenzenesulfonyl)amino]-3-methylbutyric acid benzyl ester 
• 1203835-05-5 (R)-1-(benzyloxy)-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione 
• 1203834-92-7 (R)-1-hydroxy-3-isopropyl-4-(4-methoxyphenylsulfonyl)piperazine-2,6-dione 
• 1092690-94-2 (R)-2-(N-(1-(benzyloxyamino)-3-methyl-1-oxobutan-2-yl)-4-methoxyphenylsulfonamido)acetic acid 
• 1092690-91-9 N-(4-methoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valinehydroxamic acid 
• 1092690-88-4 N-(4-methoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-D-valine 
• 182319-86-4 N-(4-methoxybenzenesulfonyl)-N-tert-butoxycarbonylmethyl-O-benzyl-D-valine 

Relevant academic research and scientific papers

Novel 1-hydroxypiperazine-2,6-diones as new leads in the inhibition of metalloproteinases

New compounds containing a novel zinc-binding group (1-hydroxypiperazine-2, 6-dione, HPD) have been identified as effective inhibitors of matrix metalloproteinases (MMPs), with activities in the nanomolar concentration range. That moiety seemed to bind th

Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: Iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates

Matrix metalloproteinases (MMPs) and carbonic anhydrases (CAs) are two classes of zinc enzymes with different roles and catalytic targets, such as the degradation of most of the extracellular matrix (ECM) proteins and the regulation of the CO2/

Sulfonamide hydroxamates

A compound of the Formula (I): wherein Z, R1, R, and Ar2are as defined in the specification. This invention also relates to sulfonamide compounds of the Formula (I) that are inhibitors of procollagen C-proteinase, pharmaceutical compositions containing them, methods for their use, and methods for preparing the compounds.

ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES

PCT No. PCT/US96/02679 Sec. 371 Date Aug. 4, 1997 Sec. 102(e) Date Aug. 4, 1997 PCT Filed Mar. 7, 1995 PCT Pub. No. WO96/27583 PCT Pub. Date Sep. 12, 1996A compound of formula (I), wherein n, X, R3, R4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scleritis and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic shock and other diseases involving the production of TNF. (I)

ARYLSULFONYLAMINO HYDROXAMIC ACID DERIVATIVES

A compound of formula (I), wherein n, X, R 3, R 4 and Ar are as defined above, useful in the treatment of a condition selected from the group consisting of arthritis, cancer, tissue ulceration, restenosis, periodontal disease, epidermolysis bullosa, scler