Cycloalkanones. 8. Hypocholesterolemic activity of long chain ketones related to pentadecanone

DOI: 10.1021/jm00224a005

Source and publish data:

Journal of Medicinal Chemistry p. 219 - 222 (1976)

Update date:2022-08-11

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Authors:

Wyrick Wyrick

Hall Hall

Piantadosi

Fenske Fenske

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Article abstract of DOI:10.1021/jm00224a005

Aliphatic analogs of 2,8 dibenzylcyclooctanone which included C₁₅-C₁₈ ketones have been investigated for hypocholesterolemic activity in rats. The position of the carbonyl group in the chain for maximum activity appears to be the 2 position. 2 Hexadecanone reduced serum cholesterol levels significantly without altering serum triglyceride levels. This drug was not estrogenic at effective doses which is in contrast to the cyclooctanones which possess this activity.

Full text of DOI:10.1021/jm00224a005

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