19781-83-0

Basic information

• Product Name: 8-HEXADECANOL
• Synonyms: N-HEPTYL N-OCTYL CARBINOL;8-HEXADECANOL
• CAS NO: 19781-83-0
• Molecular Formula: C16H34O
• Molecular Weight: 242.44
• Mol File: 19781-83-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 315.27°C (estimate)
• Flash Point: 117.8°C
• Appearance: /
• Density: 0.8323 (estimate)
• Vapor Pressure: 8.34E-05mmHg at 25°C
• Refractive Index: 1.4278 (estimate)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 8-HEXADECANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 8-HEXADECANOL(19781-83-0)
• EPA Substance Registry System: 8-HEXADECANOL(19781-83-0)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 19781-83-0(Hazardous Substances Data)

Usage

General Description

8-Hexadecanol, also known as cetyl alcohol, is a fatty alcohol that is commonly found in the form of a waxy white solid. It is derived from natural sources such as coconut and palm oil, and is widely used in the production of various skincare and cosmetic products. 8-Hexadecanol is valued for its emollient and thickening properties, and is often added to moisturizers, lotions, and hair care products to soften and condition the skin and hair. Additionally, it is also utilized as an emulsifier and stabilizer in the formulation of creams and ointments. While considered safe for topical use, excessive exposure to cetyl alcohol can cause skin irritation. Overall, 8-Hexadecanol plays a crucial role in the formulation of personal care products and contributes to their texture, consistency, and performance.

InChI:InChI=1/C16H34O/c1-3-5-7-9-11-13-15-16(17)14-12-10-8-6-4-2/h16-17H,3-15H2,1-2H3

Upstream product

• 124-13-0 Octanal 
• 17049-49-9 octylmagnesium bromide 
• 103687-22-5 ((CH₃)3C₆H₂)2BCHLiC₇H₁₅ 
• 544-76-3 Hexadecane 
• 200886-71-1 N-methoxy-N-methyloctanamide 
• 111-64-8 n-octanoic acid chloride 
• 124-07-2 Octanoic acid 
• 18277-02-6 heptyl octyl ketone 
• 1471-21-2 4-octyl-1,3,2-dioxathiolane 2-oxide 
• 1119-86-4 1,2-decanediol 
• 872-05-9 1-Decene 
• 44767-62-6 n-hexylmagnesium chloride 
• 117470-91-4 3-n-octyl-2,5-dioxathiolane 1,1-dioxide 
• 5185-99-9 undeca-1,5-diyn-4-ol 

Downstream Products

• 544-76-3 Hexadecane 
• 18277-02-6 heptyl octyl ketone 

Relevant articles and documents

CYP505E3: A Novel Self-Sufficient ω-7 In-Chain Hydroxylase

The self-sufficient cytochrome P450 monooxygenase CYP505E3 from Aspergillus terreus catalyzes the regioselective in-chain hydroxylation of alkanes, fatty alcohols, and fatty acids at the ω-7 position. It is the first reported P450 to give regioselective in-chain ω-7 hydroxylation of C10–C16 n-alkanes, thereby enabling the one step biocatalytic synthesis of rare alcohols such as 5-dodecanol and 7-tetradecanol. It shows more than 70 percent regioselectivity for the eighth carbon from one methyl terminus, and displays remarkably high activity towards decane (TTN≈8000) and dodecane (TTN≈2000). CYP505E3 can be used to synthesize the high-value flavour compound δ-dodecalactone via two routes: 1) conversion of dodecanoic acid into 5-hydroxydodecanoic acid (24 percent regioselectivity), which at low pH lactonises to δ-dodecalactone, and 2) conversion of 1-dodecanol into 1,5-dodecanediol (55 percent regioselectivity), which can be converted into δ-dodecalactone by horse liver alcohol dehydrogenase.

IONIZABLE CATIONIC LIPID FOR RNA DELIVERY

What is described is a compound of formula I consisting of a compound in which R1 is a branched chain alkyl consisting of 10 to 31 carbons;R2 is a linear alkyl, alkenyl, or alkynyl consisting of 2 to 20 carbons, or a branched chain alkyl consisting of 10 to 31 carbons;L1 and L2 are the same or different, each a linear alkane of 1 to 20 carbons or a linear alkene of 2 to 20 carbons;X1 is S or O;R3 is a linear or branched alkylene consisting of 1 to 6 carbons; andR4 and R5 are the same or different, each a hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.

Hindered organoboron groups in organic chemistry. 24. The condensation of aliphatic aldehydes with dimesitylboron stabilised carbanions to give ketones

The condensation of boron stabilised carbanions, MeS2BCHLiR1, (R1≠H) with aliphatic aldehydes, R2CHO, followed by treatment with trifluoroacetic anhydride (TFAA) or N-chlorosuccinimide (NCS) is an unique, broadly applicable redox process that yields ketones, R1CH2COR2, directly and in high yields. The anion MeS2BCH2Li (MeS2BCHLiR1, R1=H) gives high yields of alkenes, R2CH=CH2 in the same conditions.