18377-52-1Relevant academic research and scientific papers
Three isomeric N-(nitrophenyl)succinimides: Isolated molecules, hydrogen-bonded sheets and a hydrogen-bonded three-dimensional framework
Glidewell, Christopher,Low, John N.,Skakle, Janet M.S.,Wardell, James L.
, p. o216-o220 (2005)
Molecules of N-(2-nitrophenyl)succinimide, C10H 8N2O4 are linked into sheets by a combination of C-H...O and C-H...π(arene) hydrogen bonds. Molecules of N-(3-nitrophenyl)succinimide are linked into a three-dimen
Organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization: Sustainable access to indole-2,3-fused diazocanes
An, Xiao-De,Dong, Pei-Zhen,Liu, Rui-Bin,Qiu, Bin,Wang, Lin-Xuan,Xiao, Jian
supporting information, p. 8181 - 8186 (2021/11/01)
An unprecedented organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization of indole-2-carbaldehydes with o-aminoanilines was developed to assemble polycyclic indole-2,3-fused diazocanes in one step. This novel methodol
Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization
Yang, Shuo,An, Xiao-De,Qiu, Bin,Liu, Rui-Bin,Xiao, Jian
supporting information, p. 9100 - 9105 (2021/11/24)
A cascade aldimine condensation/1,6-hydride transfer/Mannich-type cyclization of indole-derived phenylenediamine with aldehydes was developed for one-step construction of a polycyclic indole-3,4-fused skeleton. Aldehyde serves as a key to start the whole process, including 1,6-hydride transfer enabled δ-C(sp3)-H activation of the secondary amine. The challenges of construction of medium-sized rings are addressed via hydride transfer chemistry.
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule
Egyed, Attila,Kelemen, ádám A.,Vass, Márton,Visegrády, András,Thee, Stephanie A.,Wang, Zhiyong,de Graaf, Chris,Brea, Jose,Loza, Maria Isabel,Leurs, Rob,Keser?, Gy?rgy M.
, (2021/04/15)
In addition to the orthosteric binding pocket (OBP) of GPCRs, recent structural studies have revealed that there are several allosteric sites available for pharmacological intervention. The secondary binding pocket (SBP) of aminergic GPCRs is located in t
