1012-81-3Relevant academic research and scientific papers
Controlling the selectivity of aminergic GPCR ligands from the extracellular vestibule
Egyed, Attila,Kelemen, ádám A.,Vass, Márton,Visegrády, András,Thee, Stephanie A.,Wang, Zhiyong,de Graaf, Chris,Brea, Jose,Loza, Maria Isabel,Leurs, Rob,Keser?, Gy?rgy M.
, (2021)
In addition to the orthosteric binding pocket (OBP) of GPCRs, recent structural studies have revealed that there are several allosteric sites available for pharmacological intervention. The secondary binding pocket (SBP) of aminergic GPCRs is located in t
Organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization: Sustainable access to indole-2,3-fused diazocanes
An, Xiao-De,Dong, Pei-Zhen,Liu, Rui-Bin,Qiu, Bin,Wang, Lin-Xuan,Xiao, Jian
supporting information, p. 8181 - 8186 (2021/11/01)
An unprecedented organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization of indole-2-carbaldehydes with o-aminoanilines was developed to assemble polycyclic indole-2,3-fused diazocanes in one step. This novel methodol
Access to Polycyclic Indole-3,4-Fused Nine-Membered Ring via Cascade 1,6-Hydride Transfer/Cyclization
Yang, Shuo,An, Xiao-De,Qiu, Bin,Liu, Rui-Bin,Xiao, Jian
supporting information, p. 9100 - 9105 (2021/11/24)
A cascade aldimine condensation/1,6-hydride transfer/Mannich-type cyclization of indole-derived phenylenediamine with aldehydes was developed for one-step construction of a polycyclic indole-3,4-fused skeleton. Aldehyde serves as a key to start the whole process, including 1,6-hydride transfer enabled δ-C(sp3)-H activation of the secondary amine. The challenges of construction of medium-sized rings are addressed via hydride transfer chemistry.
Simple and efficient synthesis of N-alkyl and N-aryl succinimides in hot water
Bozdo?an, Burcu,Er?at?r, Mehmet,Demirkol, Onur,Akba?lar, Dilek,Giray, E. Sultan
, p. 217 - 223 (2017/01/22)
A new, simple synthesis of succinimides is described. The reactions were carried out under the ultimate green conditions excluding both catalyst and organic solvent by applying simple stirring at 100 °C. A wide variety of N-susbstituted succinimides have been prepared in high yields by using succinic acid and primary amines in hot water. Yield of N-alkyl substituted succinimides were found to be higher than those of N-aryl substituted succinimides.
APPLICATION OF PHOSPHORUS, ARSENIC AND ANTIMONY REAGENTS IN THE SYNTHESIS OF HETEROCYCLIC COMPOUNDS
Alkhathlan, Hamad Z.,Al-Lohedan, Hamad A.
, p. 367 - 372 (2007/10/02)
The ability of different reagents of the type R3XBr2, where R are various alkyl, alkoxide, phenyl, and phenoxide groups, and X is P, As and Sb, to promote an intramolecular cyclization of suitably substituted aromatic diamines has been investigated.The type of R group and X was found to have a great influence on the ability of these reagents to promote this type of cyclization.Best results were obtained when R=OMe and X=P. Key words: Phosphorus; arsenic; antimony; dibromotriphenylphosphorane; diamines; heterocycles.
Dibromotriphenylphosphorane Promoted Synthesis of Condensed Heterocyclic Systems from Aromatic Diamines
Al-Khathlan, Hamad,Zimmer, Hans
, p. 1047 - 1049 (2007/10/02)
A new and rather widely applicable method for the synthesis of a number of tri, tetra-, and pentacyclic compounds from ortho-aminodiacylarylimides and dibromotriphenylphosphorane via an intramolecular cyclization is reported.A mechanism for this cyclizati
