18410-18-9

Basic information

• Product Name: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one
• Synonyms: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one;5-(4-Chlorophenyl)-3,4-dihydro-2(5H)-furanone;5-(4-Chlorophenyl)-4,5-dihydro-2(3H)-furanone;5-(4-Chlorophenyl)-4,5-dihydrofuran-2(3H)-one;Einecs 242-292-4
• CAS NO: 18410-18-9
• Molecular Formula: C₁₀H₉ClO₂
• Molecular Weight: 196.63026
• EINECS: 242-292-4
• Mol File: 18410-18-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 357.2°Cat760mmHg
• Flash Point: 193.2°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 2.77E-05mmHg at 25°C
• Refractive Index: 1.563
• CAS DataBase Reference: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(18410-18-9)
• EPA Substance Registry System: 5-(4-chlorophenyl)tetrahydrofuran-2(3H)-one(18410-18-9)

Safety Data

• Hazardous Substances Data: 18410-18-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H9ClO2/c11-8-3-1-7(2-4-8)9-5-6-10(12)13-9/h1-4,9H,5-6H2

Upstream product

• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 7148-01-8 methyl 4-(4-chlorophenyl)-4-oxobutanoate 
• 80552-14-3 C₁₀H₁₁ClO₃ 
• 99-91-2 para-chloroacetophenone 
• 29582-39-6 3-(4-chlorobenzoyl)acrylic acid 
• 14506-33-3 1-(4-chlorophenyl)but-3-en-1-ol 
• 137575-62-3 1-(4’-chlorophenyl)butan-1,4-diol 
• 102058-50-4 5-(4'-chlorophenyl)-1-penten-5-ol 
• 104-88-1 4-chlorobenzaldehyde 
• 42249-99-0 1-(4-chlorophenyl)but-3-yn-1-ol 
• 1073-67-2 4-vinylbenzyl chloride 
• 108-24-7 acetic anhydride 
• 108-90-7 chlorobenzene 
• 27374-25-0 [(1-Ethoxycyclopropyl)oxy]trimethylsilane 

Downstream Products

• 100117-11-1 4-Chlor-4-(4-chlor-phenyl)-buttersaeureethylester 
• 4157-47-5 (±)-trans-2-(4-chlorophenyl)cyclopropane-1-carboxylic acid 
• 4103-56-4 ethyl trans-2-(4-chlorophenyl)cyclopropane-1-carboxylate 
• 36159-73-6 4-(p-chlorophenyl)-1-tetralone 
• 79559-98-1 [(1R,4R)-4-(4-Chloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine; hydrochloride 
• 4521-17-9 dihydro-5-(4-chlorophenyl)-2(3H)-thiophenone 
• 137575-62-3 1-(4’-chlorophenyl)butan-1,4-diol 

Relevant articles and documents

Photo-induced radical borylation of hemiacetals via C–C bond cleavage

In this study, we reported a photo-induced radical borylation of hemiacetal derivatives via C–C bond cleavage. This transformation can be realized under mild conditions with simple reaction settings and irradiation of visible light. A series of substrates, including both cyclic and linear hemiacetal derivatives, were effectively transformed to the borylation product in moderate to good yields. Finally, the mechanism was studied in detail by DFT calculations, suggesting insight of the radical borylation process.

One-Pot γ-Lactonization of Homopropargyl Alcohols via Intramolecular Ketene Trapping

A one-pot γ-lactonization of homopropargyl alcohols via an alkyne deprotonation/boronation/oxidation sequence has been developed. Oxidation of the generated alkynyl boronate affords the corresponding ketene intermediate, which is trapped by the adjacent hydroxy group to furnish the γ-lactone. We have optimized the conditions as well as examined the substrate scope and synthetic applications of this efficient one-pot lactonization.

A sertraline hydrochloride impurity preparation method (by machine translation)

The invention discloses a sertraline hydrochloride preparation method of impurities, in particular comprising a formula 6 by the Leuckart reaction to obtain a compound of the formula 7 compound, with the insulated hydrochloride salt obtained in the reaction formula 8 cis-isomer of the compound, wherein the formula 6 compound in the location of the chloropropyl substituted cyclohexanone substituted meta or para position. Preparation method of this invention is simple, high purity, obtained impurity can be used for qualitative and quantitative analysis, so as to improve the safety of medicine sertraline hydrochloride. (by machine translation)