36159-73-6

Usage

Chemical Properties

Orange Oil

Uses

Intermediate in the preparation of Sertraline (S280000) and its derivatives.

Upstream product

• 90-15-3 α-naphthol 
• 108-90-7 chlorobenzene 
• 14578-68-8 4-phenyl-3,4-dihydronaphthalen-1(2H)-one 
• 82101-36-8 4-(o-chlorophenyl)-1-tetralone 
• 18410-18-9 γ-(4-chlorophenyl)-γ-butyrolactone 
• 71-43-2 benzene 
• 99-91-2 para-chloroacetophenone 
• 29582-39-6 3-(4-chlorobenzoyl)acrylic acid 
• 3984-34-7 4-(4-chlorophenyl)-4-oxobutanoic acid 
• 80552-14-3 C₁₀H₁₁ClO₃ 

Downstream Products

• 82101-37-9 4-(3-chlorophenyl)-1,2,3,4-tetrahydronaphth-1-one 
• 82101-36-8 4-(o-chlorophenyl)-1-tetralone 
• 79559-98-1 [(1R,4R)-4-(4-Chloro-phenyl)-1,2,3,4-tetrahydro-naphthalen-1-yl]-methyl-amine; hydrochloride 

Relevant academic research and scientific papers

A sertraline hydrochloride impurity preparation method (by machine translation)

The invention discloses a sertraline hydrochloride preparation method of impurities, in particular comprising a formula 6 by the Leuckart reaction to obtain a compound of the formula 7 compound, with the insulated hydrochloride salt obtained in the reaction formula 8 cis-isomer of the compound, wherein the formula 6 compound in the location of the chloropropyl substituted cyclohexanone substituted meta or para position. Preparation method of this invention is simple, high purity, obtained impurity can be used for qualitative and quantitative analysis, so as to improve the safety of medicine sertraline hydrochloride. (by machine translation)

REACTION OF PHENOLS AND THEIR DERIVATIVES WITH AROMATIC COMPOUNDS IN THE PRESENCE AF ACIDIC AGENTS. CONDENSATION OF 1-NAPHTHOL WITH MONOSUBSTITUTED DERIVATIVES OF BENZENE

The isomeric composition and the relative formation rates of 4-(X-phenyl)-1-tetralones in the condensation of 1-naphthol with C6H5X (X=CH3, F, Cl, H) in the presence of aluminum bromide were determined.The obtained date demonstrate the electrophilic character of the particle which is formed from 1-naphthol and subsequently enters into reaction with benzene or its derivatives.The character of electrophilic activation of the phenols and their ethers in condensation reactions of this type is discussed.