18430-91-6

Basic information

• Product Name: 1-(2-hydroxyphenyl)pentan-1-one
• Synonyms: 1-(2-Hydroxyphenyl)pentan-1-one; 1-pentanone, 1-(2-hydroxyphenyl)-
• CAS NO: 18430-91-6
• Molecular Formula: C₁₁H₁₄O₂
• Molecular Weight: 178.22766
• Mol File: 18430-91-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 271°Cat760mmHg
• Flash Point: 113°C
• Appearance: /
• Density: 1.055g/cm³
• Vapor Pressure: 0.00399mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 1-(2-hydroxyphenyl)pentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-hydroxyphenyl)pentan-1-one(18430-91-6)
• EPA Substance Registry System: 1-(2-hydroxyphenyl)pentan-1-one(18430-91-6)

Safety Data

• Hazardous Substances Data: 18430-91-6(Hazardous Substances Data)

Usage

General Description

1-(2-hydroxyphenyl)pentan-1-one, also known as 1-phenyl-2-hydroxy-1-pentanone, is a chemical compound that belongs to the class of ketones. It is a colorless to pale yellow liquid with a sweet, floral odor. 1-(2-hydroxyphenyl)pentan-1-one is commonly used as a fragrance ingredient in various cosmetic and personal care products. It also possesses antioxidant properties and can be used as a stabilizer in certain formulations. Additionally, it has been studied for its potential applications in the pharmaceutical industry, particularly as an anti-inflammatory and anti-cancer agent. Overall, 1-(2-hydroxyphenyl)pentan-1-one has various industrial and scientific uses due to its beneficial properties and potential applications.

InChI:InChI=1/C11H14O2/c1-2-3-7-10(12)9-6-4-5-8-11(9)13/h4-6,8,13H,2-3,7H2,1H3

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Relevant articles and documents

Nucleophilic addition reaction with dearomatization of naphthalene ring

Various aromatic lactones have been synthesized and their regioselectivity (1,2-addition vs. 1,4- or 1,6-addition) investigated in reactions with organolithium species, particularly n-BuLi and sec-BuLi. The regioselectivity varied greatly depending on various factors, such as the bulkiness of both substrates and organolithium species, and types of solvent and cosolvent. In particular, 1,4-addition with dearomatization occurred preferentially using sec-BuLi as the nucleophile in tetrahydrofuran (THF) with hexamethylphosphoramide (HMPA) or N,N′-dimethylpropyleneurea (DMPU) as cosolvent. For sec-BuLi, the reaction was estimated to proceed through a single-electron transfer mechanism.

Rhodium-Catalyzed Annulations of 1,3-Dienes and Salicylaldehydes/2-Hydroxybenzyl Alcohols Promoted by 2-Ethylacrolein

A rhodium-catalyzed 2-ethylacrolein-promoted protocol enables the annulation reactions of 1,3-dienes with either salicylaldehydes or 2-hydroxybenzyl alcohols leading to 2-alkylchroman-4-ones with high regioselectivity. This research highlights the use of 2-ethylacrolein which probably serves as a tool of bidentate coordination to rhodium intermediates. Mechanistic studies reveal that the transformation proceeds through the 1,4-hydroacylation pathway to access unsaturated linear ketones with subsequent oxo-Michael addition. (Figure presented.).

THIOSEMICARBAZONES INHIBITORS OF LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE AND USES THEREOF

Lysophosphatidic acid acyltransferase-beta (LPAAT-β) catalyzes the production of phosphatidic acid (PA) from lysophosphatidic acid (LPA). The lipid cofactor PA contributes to the activation of c-Raf, BRAF, mTOR and PKC-ζ. LPAAT-β expression is a prognostic factor in gynecologic malignancies and is being investigated as a therapeutic target in a variety of tumor types. A class of thiosemicarbazones was identified as inhibitors of LPAAT-β from a screen of a library of small molecules. A focused library of thiosemicarbazones derivatives was prepared and led to the development of compounds which potently inhibit LPAAT-β and inhibit the growth of MiaPaCa2 human pancreatic cancer cells.