18454-44-9

Upstream product

• 67-56-1 methanol 
• 27510-48-1 (Z)-3-(2-cyanophenyl)prop-2-enoic acid 
• 74-88-4 methyl iodide 
• 2042-37-7 o-cyanobromobenzene 
• 292638-85-8 acrylic acid methyl ester 
• 52753-91-0 (E)-methyl 3-(2-formylphenyl)acrylate 
• 7468-67-9 o-formylbenzonitrile 
• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 

Downstream Products

• 1021499-82-0 methyl 12-hydroxy-6-oxo-6H-dibenzo[c,h]chromen-11-carboxylate 
• 139437-27-7 (E)-3-(2-Cyano-phenyl)-3-phenyl-acrylic acid methyl ester 
• 959125-30-5 3-(2-cyano-phenyl)-3-(1H-indol-5-yl)-propionic acid methyl ester 
• 66192-31-2 5-phenyl-1,2,4,5-tetrahydro-benzo[c]azepin-3-one 
• 1103771-74-9 (1S)-N-tosyl-1-(2-hydroxyethyl)indoline 
• 1311201-78-1 (R)-2-(2-tosylisoindolin-1-yl)ethanol 
• 1311201-23-6 (E)-2-(3-hydroxyprop-1-enyl)benzaldehyde 
• 1311201-24-7 (E)-2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzaldehyde 
• 1311201-25-8 (E)-2-[3-(tert-butyldimethylsilyloxy)prop-1-en-yl]benzoic acid 
• 1311201-26-9 (E)-5-(2-(3-(tert-butyldimethylsilyloxy)prop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 1311201-39-4 (E)-N-(2-(3-hydroxyprop-1-enyl)benzyl)-4-methylbenzenesulfonamide 
• 1311201-77-0 (R)-2,2-dimethyl-1'-vinyl-3',4'-dihydro-1'H-spiro[[1,3]dioxane-5,2'-naphthalene]-4,6-dione 
• 1311201-27-0 (E)-5-(2-(3-hydroxyprop-1-enyl)benzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Relevant academic research and scientific papers

A ligand-free Heck reaction catalyzed by the in situ-generated palladium nanoparticles in PEG-400

A ligand-free Heck reaction catalyzed by in situ-generated palladium nanoparticles in PEG-400 has been developed. This catalytic system is a simple and active protocol for the Heck reaction of aryl halides under mild conditions. Comparative experiments de

A Bis (BICAAC) Palladium(II) Complex: Synthesis and Implementation as Catalyst in Heck-Mizoroki and Suzuki-Miyaura Cross Coupling Reactions

Carbenes are one of the most appealing, well-explored, and exciting ligands in modern chemistry due to their tunable stereoelectronic properties and a wide area of applications. A palladium complex (BICAAC)2PdCl2 with a recently discovered cyclic (alkyl)(amino)carbene having bicyclo[2.2.2] octane skeleton (BICAAC) was synthesized and characterized. The enhanced σ-donating and π-accepting ability of this carbene lend a hand to form a robust Pd-carbene bond, which allowed us to probe its reactivity as a precatalyst in Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions with low catalyst loading in open-air conditions. The diverse range of substrates was explored for both the cross-coupling reactions. To get a better understanding of the catalytic reactions, several analytical techniques such as field-emission scanning electron microscopy, high-resolution transmission electron microscopy, and powder X-ray diffraction were employed in a conclusive manner.

Hg(II) and Pd(II) complexes with a new selenoether bridged biscarbene ligand: Efficient mono- and bis-arylation of methyl acrylate with a pincer biscarbene Pd(II) precatalyst

Two equivalents of 1-benzyl-3-bromoethylbenzimidazolium bromide couple with Na2Se to produce the first selenoether bridged bis-benzimidazolium salt (LH2)Br2. The nitrate (LH2)(NO3)2 and tetrafluoroborate (LH2)(BF4)2 salts were also synthesized from (LH2)Br2. The reaction of Hg(OAc)2 with (LH2)Br2 gave the first pseudo pincer carbene mercury complex, [Hg(L-κ2C)][HgBr4] (C1). Different complexes of Pd(ii) with selenoether bridged carbene were obtained using (LH2)Br2 and (LH2)(NO3)2. Syntheses of these complexes were dependent on the counter anion and the temperature. Thus, the pincer type ionic complex [PdBr(L-κ3CSeC)]Br (C2) was isolated at 80 °C and the pseudo pincer type neutral complex cis-[PdBr2(L-κ2C)] (C3) was isolated at room temperature from (LH2)Br2 and Pd(OAc)2 in DMSO. The nitrate precursor (LH2)(NO3)2 on palladation with Pd(OAc)2 afforded [Pd(L-κ4CBzCSeC)]NO3 (C4) showing an unprecedented intramolecular metallation at the ortho position of the benzyl wingtip of the benzimidazole moiety. The ligand salts and metal complexes have been characterized using HRMS, heteronuclear NMR and IR spectroscopy. Single crystal X-ray structures of the ligand salts (LH2)Br2 and (LH2)(BF4)2 and complexes C1-C4 have also been elucidated. Complex C2 showed good activity for C-C coupling in the mono-Heck reaction of methyl acrylate and arylbromides. Interestingly, the less common bis-arylation was also observed with deactivated arylbromides as the result of double-Heck coupling.

Maghemite decorated with ultra-small palladium nanoparticles (γ-Fe2O3-Pd): Applications in the Heck-Mizoroki olefination, Suzuki reaction and allylic oxidation of alkenes

A nanocatalyst comprising ultra-small Pd/PdO nanoparticles (57Fe M?ssbauer spectroscopy. The cost-effective catalyst could be easily separated from the reaction mixture by using an external magnet and reused four times without any loss of activity; chemical stability and recyclability aspects of the catalyst were investigated.

Chemoselective Schmidt reaction mediated by triflic acid: Selective synthesis of nitriles from aldehydes

An excellent utility of Schmidt reaction of aldehydes to access corresponding nitriles in an instantaneous reaction is demonstrated. The reaction of aldehydes with NaN3 and TfOH furnishes the corresponding nitriles in near quantitative yields and tolerates a variety of electron-withdrawing and electron-donating substituents on the substrates. Formanilides, a common side product in Schmidt reaction, is not observed in this reaction. Besides these advantages, the salient feature of this reaction is that it exhibits a remarkable chemoselectivity, as acid and ketone functionalities are well tolerated under the reaction conditions. The reaction is easily scalable, high yielding, and nearly instantaneous.

DBU-CH3I, a potential substitute for CH2N2 in the preparation of methyl esters and methyl aryl ethers: Studies with assorted acids

DBU-CH3I has been poised to be a substitute for diazomethane in the preparation of methyl esters from carboxylic acids. The reactions can be carried out in commercial untreated acetone and acetonitrile, which have been exemplified with several methyl esters, otherwise it is difficult to prepare. Bis-esterification using diiodomethane can also be achieved in a similar fashion. Sufficiently acidic phenols are also conveniently O-methylated by the method. Copyright Taylor & Francis Group, LLC.

Benzazepine derivatives and uses thereof

Compounds of the formula: or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ar, R1 and R2 are defined herein. Also provided are pharmaceutical compositions, methods of preparing the compounds, and method of

Investigation of the behavior of arenediazonium salts with olefins in BmimPF6

The palladium-catalyzed reactions of olefins with arenediazonium salts in ionic liquids were investigated. For methyl acrylate and methyl acrylonitrile, normal Heck cross-coupling products are obtained in good yields. However, highly selective dimerization products are formed in excellent yields for styrenes. The catalyst system can be recycled.

Synthesis of novel tetrahydrobenzazepinones

The synthesis of novel tetrahydrobenzazepinones 1, 2, and 3 is described, as well as an improved synthesis of 4. The palladium catalyzed arylation approach to 1, 2, and 4 allows facile entry to benzazepinones lacking electron donating substituents on the

Imidazo [1,2-b][2]benzazepine and pyrimido [1,2-b][2]benzazepine antiarrhythmic agents

Novel imidazo[1,2-b][2]benzazepines and pyrimido[1,2-b][2]benzazepines of formula I, pharmaceutical compositions containing them, methods for treating cardiac arrhythmias in mammals utilizing them, and processes for synthesizing them. STR1