619-78-3

Basic information

• Product Name: Benzene, 1-(dichloromethyl)-4-nitro-
• CAS NO: 619-78-3
• Molecular Formula: C7H5Cl2NO2
• Molecular Weight: 206.028
• Mol File: 619-78-3.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(dichloromethyl)-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(dichloromethyl)-4-nitro-(619-78-3)
• EPA Substance Registry System: Benzene, 1-(dichloromethyl)-4-nitro-(619-78-3)

Safety Data

• Hazardous Substances Data: 619-78-3(Hazardous Substances Data)

Upstream product

• 98-87-3 benzylidene dichloride 
• 99-99-0 1-methyl-4-nitrobenzene 
• 555-16-8 4-nitrobenzaldehdye 
• 104-87-0 4-methyl-benzaldehyde 
• 67-64-1 acetone 
• 39184-67-3 3-chloro-3-(p-nitrophenyl)diazirine 
• 104-88-1 4-chlorobenzaldehyde 
• 99-61-6 3-nitro-benzaldehyde 
• 141-78-6 ethyl acetate 
• 623-91-6 diethyl Fumarate 
• 67-66-3 chloroform 
• 98-95-3 nitrobenzene 
• 105-07-7 4-cyanobenzaldehyde 
• 111-90-0 ethoxyethoxyethanol 

Downstream Products

• 65398-90-5 p-(1-Chloro-2-methyl-2-nitrobutyl)nitrobenzol 
• 55605-31-7 1-Chloro-2-methyl-2-nitro-(1-p-nitrophenyl)propan 
• 736-31-2 trans-4,4'-dinitrostilbene 
• 3284-64-8 1-nitro-4-(trichloromethyl)benzene 
• 555-16-8 4-nitrobenzaldehdye 
• 83966-41-0 C₇H₅ClNO₂ 
• 4100-96-3 α,α,α',α'-tetrachloro-4,4'-dinitro-bibenzyl 
• 29848-60-0 N-[4-(difluoromethyl)phenyl]acetamide 

Relevant articles and documents

One-pot, oxidative and selective conversion of benzylic silyl and tetrahydropyranyl ethers to gem-dichlorides using trichloroisocyanuric acid and triphenylphosphine as an efficient and neutral system

A one-pot and oxidative method is described for the first time for the conversion of benzylic trimethylsilyl (TMS) and tetrahydropyranyl (THP) ethers to gem-dichlorides using trichloroisocyanuric acid (TCCA) and triphenylphosphine (PPh3) in neutral media. Various theses substrates containing electron withdrawing or donating groups can be efficiently converted to their corresponding gem-dichlorides in good to excellent yields. The present method shows a high degree of chemoselectivity, and due to its one-pot nature is in accordance with green chemistry.

Formamide Catalysis Facilitates the Transformation of Aldehydes into Geminal Dichlorides

Herein, a novel method for the transformation of aldehydes into geminal dichlorides based on phthaloyl chloride as reagent and N -formylpyrrolidine as Lewis base catalyst is disclosed. Given the mild reaction conditions, the current protocol is distinguished by high levels of functional group compatibility and scalability and is operationally simple. The in situ formation of a Vilsmeier Haack reagent type intermediate is likely to be essential for this organocatalytic nucleophilic substitution reaction.

Synthesis of Aryldihalomethanes by Denitrogenative Dihalogenation of Benzaldehyde Hydrazones

We report a denitrogenative dihalogenation reaction of phenyldiazomethanes in which the hypervalent iodine reagents PhICl2 and TolIF2 act as surrogates for elemental chlorine and fluorine. Halogen transfer from iodane to aryldiazomethane is described, as is a tandem oxidative dihalogenation reaction between iodane and hydrazone. This is the first use of non-α-stabilized diazo compounds in this reaction, which provided an efficient synthesis of aryldifluoromethane (ArCHF2) and aryldichloromethane (ArCHCl2) derivatives. (Figure presented.).