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18507-89-6

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18507-89-6 Usage

Highly Effective Anti-coccidiosis for Livestock and Poultry

Decoquinate is a new type highly-efficienct quinolones anti-coccidiosis for livestock and poultry, commonly known as quinoxetine, decanoquinolate, paclitaxel, to quinolate, benzoquinone. The active compound is white or slightly yellow crystalline powder, rarely soluble in chloroform or ether, insoluble in water or ethanol. It has a unique anti-coccidial activity stronger than Maduramicin, nicarbazine + Ethanamidobenzylate, methyl salicin. Studies have shown that decanoquinolines are effective in combating the resistance from coccidium and are clinically used to control the most harmful poultry coccidiosis caused by E.tenella, E.maxima, E.acerVulina, E.necatrix, E.brunetti, E.mivati). it can also effect in the precaution of neosporosis in livestocks of cattle and sheep. It can improve the weight growth rate and milk yield of young goat. Decoquinate plays a role in the asexual reproduction of coccidia, and after entering the sporozoite cell, it prevents its development by interfering with DNA synthesis. It begins to function in the early stages of life history of coccidia, effectively prevents the coccidia caused by intestinal damage. Addition of decoquinate in the fodder does not affect the digestion of the fodder and the absorption of nutrients. This product has no incompatibility except that it can not be used in the feed containing bentonite. Quinoline anticoccidial drugs are easy to be resisted. It is recommended continuous use of up to no more than 4 weeks be applied only in the peak period of coccidia,. Since the 1970s, decanoquinolines have been widely used in the control of coccidiosis in poultry in many countries, but have not been used in China. In 2006, the Alpharma (U.S.) first introduced quinoline into China market, which had aroused wide attention. Its first use in China had presented no drug resistance, its use as ideal alternative, killing effect on coccidia, promoting effect on growth, improvement effect on the color, excellent anticoccidial effect and growth performance in the early life; it starts to play a role in the early stages of life history of coccidia with the longest effect duration and a wide anticoccidial spectrum. It has extermination effect on the most harmful 6 avian coccidia with an excellent stability. It can keep stable quality for 4 years at proper temperature and humidity. At present, Healthy (Hangzhou) Husbandry Sci-tech Co., Ltd, Shandong Sinder Technology Co., Ltd produce and market decoquinate APIs.

Chemical and Physical Properties

Light yellow crystalline powder; Melting point at 86-87 DEG C; Slightly soluble in chloroform, ether, almost insoluble in water; Odorless.

Toxicological Information

Decoquinate is well tolerated with low toxicity and dosage 80 times of the recommended is still safe. Poultry: addition of 800ppm in fodder (26 times the normal dosage) with continuous feeding for 127 days caused no poisoning; Pigs: 800ppm continuous feeding for 10 days caused no poisoning.

Pharmacokinetics

Decoquinate is fast absorpted. It reaches the effective concentration within 1 hour and its peak level 3 days after. On the 5th days and 7th days after the administration of unlabeled qecoquinate on the cattle and sheep, a single dose of this product labeled with 14C was intravenously injected into the cattle, sheep and the plasma radiation reaches the peak 1.5 hours after. Decoquinate is partially metabolized in the rat body, resulting in three kinds of metabolites, but the structure cannot be determined. Only two of its metabolites are identified in ruminants, and the proportion is lower than that of rats. Its main excretion in ruminants is manure, followed by urine. In sheep, urine excreted 36% of the total dose and 35% is discharged within 24 hours; qecoquinate and its metabolites in urinary is completely discharged in 3 days.

Applications

Quinoline coccidia; Used as a feed additive (27.2g in 1t feed) to prevent broiler coccidiosis. This product of low toxicity and good tolerance has a wide dosage range of safety. Its rapid metabolism entitles it a withdrawal in 3 days with the residual drug concentration in each tissue is less than 1ppm.

Drug Combination

In order to improve the anti-coccidia effect and reduce drug resistance, you can take a combination of drugs. In the early stages of coccidiosis (coccidiosis asexual breeding period) using decanoquinate + diclazuril, calcitonizumole or deccox + maduramicin, deccox + chloropyridine and other combination therapy to perform a synergistic effect of drugs to enhance the killing effect, while the use of each drug can reduce 1/2. In the fully outbreak period of coccidiosis, the use of deccox +sodium sulfaquinoxaline, deccox + SPZ and other combination therapy can inhibit and kill coccidium in asexual breeding and sexual reproduction.

Synthesis Method

3,4-dihydroxy nitrobenzene reacts with bromodecane in DMF medium to produce 3-hydroxy-4-decyloxy nitrobenzene. And the product is then ethoxylated and reduced to produce 3-ethoxy-4-decyloxyaniline. Then, 3-ethoxy-4-decyloxyaniline is condensed with diethyl ethoxymethylenemalonate to produce 3-ethoxy-4-decyloxyanilide methylidene malonate ester, which is finally transformed into finished product through heat condensation with dowtherm A.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 18507-89-6 differently. You can refer to the following data:
1. Decoquinate is a quinolone coccidiostat used in veterinary medicine, in particular as animal feed for poultry.
2. monoxycarbolic acid antibiotic
3. antiviral

Veterinary Drugs and Treatments

Decoquinate is labeled for use in cattle for the prevention of coccidiosis in either ruminating or non-ruminating calves, cattle or young goats caused by the species E. christenseni or E. ninakohlyakimoviae. It is used for prevention of coccidiosis in broilers caused by E. tenella, E. necatrix, E. acervulina, E. mivati, E. maxima or E. burnetti. It may be useful in dogs as prophylactic treatment for coccidiosis and hepatozoonosis relapse.

Check Digit Verification of cas no

The CAS Registry Mumber 18507-89-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,8,5,0 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 18507-89:
(7*1)+(6*8)+(5*5)+(4*0)+(3*7)+(2*8)+(1*9)=126
126 % 10 = 6
So 18507-89-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H35NO5/c1-4-7-8-9-10-11-12-13-14-30-21-15-18-20(16-22(21)28-5-2)25-17-19(23(18)26)24(27)29-6-3/h15-17H,4-14H2,1-3H3,(H,25,26)

18507-89-6 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (D4192)  Decoquinate  >97.0%(HPLC)(N)

  • 18507-89-6

  • 1g

  • 860.00CNY

  • Detail
  • USP

  • (1165408)  Decoquinate  United States Pharmacopeia (USP) Reference Standard

  • 18507-89-6

  • 1165408-200MG

  • 4,723.29CNY

  • Detail
  • Sigma-Aldrich

  • (33823)  Decoquinate  VETRANAL, analytical standard

  • 18507-89-6

  • 33823-100MG

  • 1,574.82CNY

  • Detail

18507-89-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl 6-decoxy-7-ethoxy-4-oxo-1H-quinoline-3-carboxylate

1.2 Other means of identification

Product number -
Other names 6-decyloxy-7-ethoxy-4-hydroxy-quinoline-3-carboxylic acid ethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:18507-89-6 SDS

18507-89-6Related news

Decoquinate (cas 18507-89-6) induces tissue cyst formation by the RH strain of Toxoplasma gondii09/27/2019

Decoquinate is an anticoccidial agent that inhibits respiration in the parasites mitochondrion. We examined human foreskin fibroblast cell cultures infected with the normally tissue cyst-less RH strain of Toxoplasma gondii and treated with decoquinate for evidence of tissue cyst induction and fo...detailed

Efficacy of Decoquinate (cas 18507-89-6) against Neospora caninum tachyzoites in cell cultures09/26/2019

Neospora caninum is a major cause of abortion in dairy cattle in the United States and other countries. Abortions and neonatal mortality also occur in other ruminant species. Decoquinate is an anticoccidial that is approved for use in cattle and goats in the United States. We studied the efficac...detailed

Short communicationActivity of Decoquinate (cas 18507-89-6) against Cryptosporidium parvum in cell cultures and neonatal mice09/25/2019

Cryptosporidium parvum is an apicomplexan parasite that is an important cause of diarrhea in neonatal calves and humans. No treatment is currently available for neonatal calves. We have recently learned from colleagues in the pharmaceutical industry that dairy practitioners are sometimes using d...detailed

Tracing the emergence of drug-resistance in coccidia (Eimeria spp.) of commercial broiler flocks medicated with Decoquinate (cas 18507-89-6) for the first time in the United Kingdom09/24/2019

Decoquinate is a quinolone coccidiostat introduced during 1967 as an in-feed prophylactic for broiler chickens. Despite early drug-resistance problems and its age, the drug is still used commercially worldwide. Decoquinate here serves as a valuable model in a field study that addresses the dynam...detailed

Efficacy of Decoquinate (cas 18507-89-6) against drug sensitive laboratory strains of Eimeria tenella and field isolates of Eimeria spp. in broiler chickens in China09/10/2019

The efficacy of decoquinate against Eimeria infections in broiler chickens was evaluated using two drug sensitive laboratory strains of Eimeria tenella and 20 field isolates of Eimeria spp. collected from farms in China where various anticoccidials (including maduramicin) had been used. Decoquin...detailed

Research ArticleNanoparticle formulations of Decoquinate (cas 18507-89-6) increase antimalarial efficacy against liver stage Plasmodium infections in mice09/09/2019

Decoquinate has potent activity against both Plasmodium hepatic development and red cell replication when tested in vitro. Decoquinate, however, is practically insoluble in water. To achieve its maximal in vivo efficacy, we generated nanoparticle formulations of decoquinate with a mean particle ...detailed

Straightforward conversion of Decoquinate (cas 18507-89-6) into inexpensive tractable new derivatives with significant antimalarial activities09/08/2019

As part of a programme aimed at identifying rational new triple drug combinations for treatment of malaria, tuberculosis and toxoplasmosis, we have selected quinolones as one component, given that selected examples exhibit exceptionally good activities against the causative pathogens of the fore...detailed

Efficacy of Decoquinate (cas 18507-89-6) against Sarcocystis neurona in cell cultures09/06/2019

Decoquinate is a quinolone anticoccidial approved for use in the prevention of intestinal coccidiosis in farm animals. This compound has good activity against Toxoplasma gondii and Neospora caninum in cell cultures. The drug acts on the parasites’ mitochondria. The activity of decoquinate again...detailed

Research paperRepurposing of commercially available anti-coccidials identifies diclazuril and Decoquinate (cas 18507-89-6) as potential therapeutic candidates against Besnoitia besnoiti infection09/05/2019

Repurposing of currently marketed compounds with proven efficacy against apicomplexan parasites was used as an approach to define novel candidate therapeutics for bovine besnoitiosis. Besnoitia besnoiti tachyzoites grown in MARC-145 cells were exposed to different concentrations of toltrazuril, ...detailed

18507-89-6Relevant articles and documents

Synthetic method of decoquinate

-

, (2018/03/01)

The invention discloses a synthetic method of decoquinate, and belongs to the technical field of pharmaceutical engineering. The synthetic method takes o-hydroxyphenyl ethyl ether as a raw material to prepare decoquinate via the processes of coupling, reduction, condensation, etherification, cyclization and the like. The process of reduction in the method adopts environment-friendly hydrazine hydrate as a reducer to reduce an azo-compound and introduce an amino group, so that the synthetic method is good in selectivity, and environmentally friendly, and beneficial for reducing environmental pollution problems; BTC is adopted as a cyclization reagent in the process of cyclization, so that the condition is mild, the requirement on equipment is lowered, and the cost is reduced.

Convenient and efficient preparation of ethyl 6-n-decyloxy-7-ethoxy-4- hydroxyquinoline-3-carboxylate

Xu, Maoyou,Zhang, Jin,Wu, Xue,Sun, Juanjuan,Shi, Zhiqiang

experimental part, p. 992 - 997 (2010/05/18)

Ethyl 6-N-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate has been synthesized from pyrocatechol in six steps and in 39.3% overall yield.

Process for formulating a synthetic drug for use in animal feed, and resulting formulation

-

, (2008/06/13)

A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.

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