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1851-09-8

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1851-09-8 Usage

Chemical Properties

white powder

Uses

(4-Chlorophenylsulfonyl)acetonitrile react with trimethoxymethyl-benzene, and gives 2-(4-chloro-benzenesulfonyl)-3-methoxy-3-phenyl-acrylonitrile.

Check Digit Verification of cas no

The CAS Registry Mumber 1851-09-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,5 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1851-09:
(6*1)+(5*8)+(4*5)+(3*1)+(2*0)+(1*9)=78
78 % 10 = 8
So 1851-09-8 is a valid CAS Registry Number.
InChI:InChI=1/C8H6ClNO2S/c9-7-1-3-8(4-2-7)13(11,12)6-5-10/h1-4H,6H2

1851-09-8 Well-known Company Product Price

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  • TCI America

  • (C1236)  4-Chlorophenyl Cyanomethyl Sulfone  >98.0%(GC)

  • 1851-09-8

  • 5g

  • 675.00CNY

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  • Alfa Aesar

  • (A14510)  (4-Chlorophenylsulfonyl)acetonitrile, 98+%   

  • 1851-09-8

  • 1g

  • 267.0CNY

  • Detail
  • Alfa Aesar

  • (A14510)  (4-Chlorophenylsulfonyl)acetonitrile, 98+%   

  • 1851-09-8

  • 5g

  • 545.0CNY

  • Detail
  • Alfa Aesar

  • (A14510)  (4-Chlorophenylsulfonyl)acetonitrile, 98+%   

  • 1851-09-8

  • 25g

  • 2269.0CNY

  • Detail

1851-09-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(4-chlorophenyl)sulfonylacetonitrile

1.2 Other means of identification

Product number -
Other names 2-((4-Chlorophenyl)sulfonyl)acetonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1851-09-8 SDS

1851-09-8Relevant articles and documents

Unexpected Aldehyde-Catalyzed Reaction of Imidazole N -Oxides with Ethyl Cyanoacetate

Efimova, Anna S.,Kutasevich, Anton V.,Kuz'Mina, Ludmila G.,Mityanov, Vitaly S.,Perevalov, Valery P.,Sizonenko, Marina N.

, p. 179 - 182 (2020)

The reaction of 2-unsubstituted imidazole N -oxides with ethyl cyanoacetate and aromatic aldehydes leads to the formation of ethyl 2-cyano-2-(1,3-dihydro-2 H -imidazole-2-ylidene)acetates. The reaction proceeds through an initial [3+2] cycloaddition, followed by cleavage of the cycloadduct and regeneration of the aldehyde, which essentially plays a catalytic role.

Photoinduced synthesis of 2-sulfonylacetonitriles with the insertion of sulfur dioxide under ultraviolet irradiation

Zhou, Kaida,Liu, Jin-Biao,Xie, Wenlin,Ye, Shengqing,Wu, Jie

supporting information, p. 2554 - 2557 (2020/03/10)

Metal-free insertion of sulfur dioxide with aryl iodides and 3-azido-2-methylbut-3-en-2-ol under ultraviolet irradiation at room temperature is achieved, giving rise to 2-(arylsulfonyl)acetonitriles in moderate to good yields. Alkyl iodide is also workable under these conditions. This transformation proceeds smoothly under mild conditions with a broad substrate scope. Various functional groups are compatible including amino, ester, halo, and trifluoromethyl groups. No metal catalyst or additive is needed during the reaction process. Mechanistic studies show that under ultraviolet irradiation, an aryl radical is generated in situ from aryl iodide, which undergoes subsequent sulfonylation via the insertion of sulfur dioxide leading to arylsulfonyl radical intermediates. Then the arylsulfonyl radical reacts with 3-azido-2-methylbut-3-en-2-ol giving rise to the corresponding 2-(arylsulfonyl)acetonitrile.

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors

Kim, Junwon,Kwon, Jeongjin,Lee, Doohyun,Jo, Suyeon,Park, Dong-Sik,Choi, Jihyun,Park, Eunjung,Hwang, Jong Yeon,Ko, Yoonae,Choi, Inhee,Ju, Moon Kyeong,Ahn, Jiye,Kim, Junghwan,Han, Sung-Jun,Kim, Tae-Hee,Cechetto, Jonathan,Nam, Jiyoun,Ahn, Sujin,Sommer, Peter,Liuzzi, Michel,No, Zaesung,Lee, Jinhwa

, p. 153 - 157 (2013/02/23)

We identified a novel class of triazolothienopyrimidine (TTPM) compounds as potent HIV-1 replication inhibitors during a high-throughput screening campaign that evaluated more than 200,000 compounds using a cell-based full replication assay. Herein, we report the optimization of the antiviral activity in a cell-based assay system leading to the discovery of aryl-substituted TTPM derivatives (38, 44, and 45), which exhibited significant inhibition of HIV-1 replication with acceptable safety margins. These novel and potent TTPMs could serve as leads for further development.

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