1851-90-7Relevant articles and documents
Synthesis of [1-11C]-2-octynoic acid, [1-11C]-2-decynoic acid and [1-11C]-3-(R,S)-methylocatanoic acid as potential markers for PET studies of fatty acid metabolism
Kawashima, Hidefumi,Yajima, Kazuyoshi,Kuge, Yuji,Hashimoto, Naoto,Miyake, Yoshihiro
, p. 181 - 193 (1997)
[1-11C]-2-Octynoic acid, [1-11C]-2-decynoic acid and [1-11C]-3-(R,S)-methyloctanoic acid have been synthesized in order to evaluate these compounds as PET (Positron Emission Tomography) tracers for imaging in vivo medium-chain acyl-CoA dehydrogenase and medium-chain fatty acid utilization. The synthesis was performed by the Grignard reaction between alkylmagnesium bromides and [11C]CO2. The radiochemical yields of [1-11C]-2-octynoic acid, [1-11C]-2-decynoic acid, and [1-11C]-3-(R,S)-methyloctanoic acid were 10, 7 and 1% based on the [11C]CO2 used respectively. Radiochemical purity was >99% in all cases.
CONTROLLING BIOFILMS WITH CYCLOPROPANATED FATTY ACIDS
-
Paragraph 0098-0099, (2020/05/29)
Compositions and methods for using cyclopropanated structural analogs of fatty acid biofilm dispersal agents are characterized by superior biofilm dispersion. When used in combination with antimicrobials, these analogs decrease the minimum inhibitory concentration of antimicrobial agents required for eradication of the biofilm and/or treatment of infection. Methods for using these analogs include direct application to a surface, blending with lipid based carriers, or covalent anchoring the molecule to a surface.
Electrochemical selective incorporation of CO2 into terminal alkynes and diynes
Ko?ster, Frank,Dinjus, Erkhardt,Din?ach, Elisabet
, p. 2507 - 2511 (2007/10/03)
Electrochemical incorporation of CO2 into terminal alkynes and diynes on silver cathodes occurred selectively, to afford monocarboxylic acid derivatives in good yields. The electrolyses were carried out in one-compartment cells fitted with magnesium anodes, under mild conditions.