Synthesis of [1-11C]-2-octynoic acid, [1-11C]-2-decynoic acid and [1-11C]-3-(R,S)-methylocatanoic acid as potential markers for PET studies of fatty acid metabolism

Article abstract of DOI:10.1002/(SICI)1099-1344(199703)39:3<181::AID-JLCR962>3.0.CO;2-W

[1-¹¹C]-2-Octynoic acid, [1-¹¹C]-2-decynoic acid and [1-¹¹C]-3-(R,S)-methyloctanoic acid have been synthesized in order to evaluate these compounds as PET (Positron Emission Tomography) tracers for imaging in vivo medium-chain acyl-CoA dehydrogenase and medium-chain fatty acid utilization. The synthesis was performed by the Grignard reaction between alkylmagnesium bromides and [¹¹C]CO₂. The radiochemical yields of [1-¹¹C]-2-octynoic acid, [1-¹¹C]-2-decynoic acid, and [1-¹¹C]-3-(R,S)-methyloctanoic acid were 10, 7 and 1% based on the [¹¹C]CO₂ used respectively. Radiochemical purity was >99% in all cases.