185106-16-5

Basic information

• Product Name: AcotiaMide
• Synonyms: AcotiaMide;N-[2-[Bis(1-methylethyl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-4-thiazolecarboxamide;N-(2-(diisopropylamino)ethyl)-2-(2-hydroxy-4,5-dimethoxybenzamido)thiazole-4-carboxamide hydrochloride;Acofide;ACOTIAMIDUM
• CAS NO: 185106-16-5
• Molecular Formula: C21H30N4O5S
• Molecular Weight: 450.5517
• Mol File: 185106-16-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.246g/cm³
• Refractive Index: 1.591
• PKA: 7.38±0.50(Predicted)
• CAS DataBase Reference: AcotiaMide(CAS DataBase Reference)
• NIST Chemistry Reference: AcotiaMide(185106-16-5)
• EPA Substance Registry System: AcotiaMide(185106-16-5)

Safety Data

• Hazardous Substances Data: 185106-16-5(Hazardous Substances Data)

Usage

General Description

Acotiamide is a medication that is primarily used to treat functional dyspepsia, a condition characterized by symptoms such as bloating, nausea, and early satiety. It works by increasing the release of acetylcholine, a neurotransmitter that stimulates the movement of food through the digestive system and enhances gastric emptying. Acotiamide is a unique drug in that it selectively targets the M1 and M2 muscarinic receptors in the gut, without affecting the muscarinic receptors in other parts of the body, which helps to minimize side effects. Studies have shown that acotiamide can effectively reduce dyspeptic symptoms and improve overall quality of life in patients with functional dyspepsia.

InChI:InChI=1/C21H30N4O5S/c1-12(2)25(13(3)4)8-7-22-20(28)15-11-31-21(23-15)24-19(27)14-9-17(29-5)18(30-6)10-16(14)26/h9-13,26H,7-8H2,1-6H3,(H,22,28)(H,23,24,27)

Upstream product

• 610-90-2 2,4,5-trihydroxybenzoic acid 
• 28373-21-9 2-hydroxy-4,5-dimethoxybenzoic acid methyl ester 
• 42833-66-9 2,4,5-trimethoxybenzoyl chloride 
• 185105-98-0 ethyl 2-[(2,4,5-trimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylate 
• 7087-68-5 N-ethyl-N,N-diisopropylamine 
• 121-05-1 N',N'-diisopropyl-ethane-1,2-diamine 
• 61203-48-3 2-iodo-4,5-dimethoxybenzoic acid 
• 877997-98-3 2-hydroxy-4,5-dimethoxybenzoic acid phenyl ester 
• 5722-93-0 2-hydroxy-4,5-dimethoxybenzoic acid 
• 877997-99-4 2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxylic acid methyl ester 
• 490-64-2 asaronic acid 

Relevant articles and documents

Industrial production method of acotiamide hydrochloride

The invention discloses an industrial production method of acotiamide hydrochloride. The industrial production method comprises the following steps that firstly, 2,4,5-trimethoxy benzoic acid serves as an initial raw material, acylating chlorination is ca

Method for synthesizing acotiamide hydrochloride

The invention discloses a method for synthesizing acotiamide hydrochloride. According to the method, 2,4,5-trimethoxybenzoic acid, thionyl chloride, methylbenzene, dichloromethane, 2-aminothiazole-4-ethyl formate, N-N-dimethyl formamide, pyridine Hydrochl

arab League tests for the amine and a method for the preparation of its hydrochloride (by machine translation)

The invention discloses a arab League tests for the amine method for preparing and its hydrochloride, 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxylic acid methyl ester, and N, N-diisopropyl ethylenediamin in the molten state after reaction under N-[ 2 - (diisopropyl amino) ethyl] - 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 1,3-thiazole-4-carboxamide, hydrochloric acid for hydrochloric acid prepared by adding dropwisely added methanol trihydrate arab League takes a test for somebody else the amine, the technical proposal of the present invention reduces the use of toluene, economic and convenient, the reaction is complete, process safety; reduced at the same time the residual toluene in the final product, and impurity 2 - [(2-hydroxy -4,5-dimethoxy-benzoyl) amino] - 4-carboxyl -1, the content of 3-thiazole, the product quality is promoted; and is easy to be refined and purification of the crude product, the reaction yield is high. (by machine translation)