185449-80-3 Usage
Description
(R)-MONOPHOS, a member of the DSM MonoPhos family, is a highly efficient privileged ligand used in various chemical reactions. It is characterized by its ability to facilitate asymmetric hydrogenation of ketones and β-keto esters, as well as light-induced, enantioselective hydrogenation. These properties make (R)-MONOPHOS a valuable tool in the field of chemistry, particularly in the synthesis of chiral compounds.
Uses
Used in Asymmetric Hydrogenation:
(R)-MONOPHOS is used as a ligand in asymmetric hydrogenation reactions for the production of chiral compounds. It plays a crucial role in enhancing the enantioselectivity and efficiency of these reactions, leading to the formation of desired enantiomers with high purity.
Used in Light-Induced Enantioselective Hydrogenation:
(R)-MONOPHOS is also used as a ligand in light-induced, enantioselective hydrogenation processes. This application takes advantage of the ligand's ability to control the stereochemistry of the reaction, allowing for the selective formation of specific enantiomers under the influence of light.
Used in the DSM MonoPhos Family of Ligands:
(R)-MONOPHOS is a part of the DSM MonoPhos family of highly efficient privileged ligands, which are widely used in various chemical reactions and industries. These ligands are known for their exceptional performance in promoting asymmetric catalysis, making them valuable assets in the synthesis of complex molecules and pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 185449-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,5,4,4 and 9 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 185449-80:
(8*1)+(7*8)+(6*5)+(5*4)+(4*4)+(3*9)+(2*8)+(1*0)=173
173 % 10 = 3
So 185449-80-3 is a valid CAS Registry Number.
185449-80-3Relevant articles and documents
Palladium-Catalyzed Diastereoselective Synthesis of (Z)-Conjugated Enynyl Homoallylic Alcohols
Horino, Yoshikazu,Ishibashi, Mayo,Sakamoto, Juri,Murakami, Miki,Korenaga, Toshinobu
supporting information, p. 3592 - 3599 (2021/06/15)
The diastereoselective synthesis of anti-homoallylic alcohols bearing conjugated (Z)-enynes through a palladium-catalyzed three-component reaction is described. This reaction features a broad substrate scope, good functional group compatibility, and high levels of (Z)-alkene stereocontrol. In this reaction, Pd(0) functions as a catalyst in two fundamental steps of the tandem sequence: 1) the generation of a borylated π-allylpalladium species from bifunctional conjunctive reagents, inducing umpolung allylation of aldehydes, and 2) C(sp2)?C(sp) cross-coupling. Further transformations of the obtained products highlight their synthetic utility. (Figure presented.).
Synthesis of Chiral Phosphorus Reagents and Their Catalytic Activity in Asymmetric Borane Reduction of N-Phenyl Imine of Acetophenone
Kangying, Li,Zhenghong, Zhou,Guofeng, Zhao,Chuchi, Tang
, p. 546 - 550 (2007/10/03)
Eleven chiral trivalent or quatrivalent phosphorus reagents were synthesized starting from L-proline, D-camphor, (+)- or (-)-1,1'-binaphthalene-2,2'-diol, (-)-α-phenylethylamine, etc. and their application as catalysts in asymmetric borane reduction of N-