1863-21-4

Basic information

• Product Name: 7-phenyl-1H-indole
• Synonyms: 1H-indole, 7-phenyl-; 7-Phenyl-1H-indole
• CAS NO: 1863-21-4
• Molecular Formula: C₁₄H₁₁N
• Molecular Weight: 193.2438
• Mol File: 1863-21-4.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 392.547°C at 760 mmHg
• Flash Point: 176.574°C
• Density: 1.156g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: 7-phenyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 7-phenyl-1H-indole(1863-21-4)
• EPA Substance Registry System: 7-phenyl-1H-indole(1863-21-4)

Safety Data

• Hazardous Substances Data: 1863-21-4(Hazardous Substances Data)

Upstream product

• 51417-51-7 7-bromo-1H-indole 
• 108-86-1 bromobenzene 
• 642494-37-9 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)-1H-indole 
• 577-19-5 2-nitrophenyl bromide 
• 98-80-6 phenylboronic acid 
• 86-00-0 2-nitrobiphenyl 
• 1826-67-1 vinyl magnesium bromide 
• 88615-24-1 N,N,N’,N’-tetramethyl-P-indol-1-ylphosphonic diamide 
• 108-90-7 chlorobenzene 
• 2996-92-1 phenyl trimethylsiloxane 
• 780-69-8 triethoxyphenylsilane 
• 496-15-1 1-indoline 
• 120-72-9 indole 

Downstream Products

• 1265815-39-1 3,3,3-trifluoro-2-hydroxy-2-(7-phenyl-1H-indol-3-yl)-propionic acid ethyl ester 
• 1265815-74-4 3,3,3-trifluoro-2-hydroxy-2-(7-phenyl-1H-indol-3-yl)-propionic acid ethyl ester 
• 1265815-86-8 3,3,3-trifluoro-2-hydroxy-2-(7-phenyl-1H-indol-3-yl)-propionic acid ethyl ester 
• 92199-07-0 7-phenylindoline 
• 1254363-77-3 1-((4-methoxyphenyl)sulfonyl)-7-phenylindoline 
• 480435-87-8 2,5-dichloro-3-(7-phenyl-1H-indol-3-yl)[1,4]benzoquinone 

Relevant articles and documents

Synthesis of 7-pentafluorophenyl-1 H -indole: An anion receptor for anion-π interactions

7-Pentafluorophenyl-1H-indole has the potential to be a key compound for the investigation of anion-π interactions in solution. Unfortunately, it was not possible to obtain it by aryl-aryl coupling reaction. Finally, it has been prepared by Bartoli indole synthesis. The key compound as well as analogues were submitted to preliminary studies of anion binding. Single crystals of two key receptors were obtained. Georg Thieme Verlag Stuttgart New York.

Intermolecular Nucleophilic Addition Reaction of a C-7 Anion from N -[Bis(dimethylamino)phosphoryl]indole to Electrophiles/Arynes: Synthesis of 7-Substituted Indoles

A novel approach to the C-7 substitution of N-[bis(dimethylamino)phosphoryl]indole by nucleophilic addition of the corresponding C-7 carbanion to electrophiles or arynes is described. The directing group can be easily removed, providing a simple route to the synthesis of 7-functionalized indoles.

Preparation method of 7-phenylindole compound

The invention discloses a preparation method of a 7-phenylindole compound. Indole is used as a starting raw material, under the condition that n-butyllithium is used as an alkali, a di-tert-butylphosphine guide group is introduced to the C1 site of an indole ring, a steric effect and a coordination effect are utilized to activate a carbon-hydrogen bond at the C7 site of the indole ring, and palladium acetate is adopted to catalyze an organic tin reagent to perform a carbon-carbon bond coupling reaction, so that arylation of the C7 site of the indole ring is realized; and by taking tetrabutylammonium fluoride as an alkaline condition, removing of the di-tert-butylphosphine guide group is carried out to obtain the 7-phenylindole compound. According to the method, halogenation does not need to be conducted at the C7 position of the indole ring in advance, the optimized reaction condition is mild, the substrate universality is good, the reaction yield is high, and the method is a new method for synthesizing the 7-phenylindole compound.