18657-14-2

Upstream product

• 106-95-6 allyl bromide 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 106-92-3 Allyl glycidyl ether 
• 67-64-1 acetone 
• 123-34-2 3-allyloxy-1,2-propanediol 
• 77-76-9 2,2-dimethoxy-propane 
• 107-05-1 3-chloroprop-1-ene 
• 98760-27-1 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane 

Downstream Products

• 123-34-2 3-allyloxy-1,2-propanediol 
• 123-34-2 (R)-3-allyloxypropane-1,2-diol 
• 123-34-2 (S)-3-allyloxy-propane-1,2-diol 
• 595605-52-0 (R)-(+)-3-tert-butyldiphenylsilyl-1-O-(1'-(Z)-hexadecenyl)-2-(2-trimethylsilanylethoxymethyl)glycerol 
• 595605-51-9 (R)-(+)-1-allyl-3-tert-butyldiphenylsilyl-2-(2-trimethylsilanylethoxymethyl)glycerol 
• 595605-50-8 (R)-(+)-1-allyl-3-tert-butyldiphenylsilyl-sn-glycerol 
• 55207-76-6 2-(allyloxy)acetaldehyde 
• 117606-90-3 (R)-1-O-allyl-3-O-benzylglycerol 
• 95043-55-3 (+)-3-(allyloxy)-1,2-epoxypropane 

Relevant academic research and scientific papers

Efficient and catalytic conversion of epoxides into 1,3-dioxolanes with LiBF4

Lithium tetrafluoroborate catalysis the efficient conversion of epoxides with acetone to the corresponding 1,3-dioxolanes in excellent isolated yields. Copyright Taylor & Francis, Inc.

Efficient and Catalytic Conversion of Epoxides to 1,3-Dioxolanes with TiO(TFA)2 or TiCl3(OTf)

TiO(TFA)2 or TiCl3(OTf) catalyses the efficient reaction of epoxides with acetone to give the corresponding 1,3-dioxolanes in excellent yields. The reaction of chiral styrene oxide was found to be highly stereospecific.

Efficient conversion of epoxides to 1,3-dioxolanes catalyzed by bismuth(III) salts

Epoxides react with acetone in the presence of catalytic amounts of bismuth(III) salts including BiCl3, Bi(TFA)3 and Bi(OTf)3 affording the corresponding 1,3-dioxolanes in excellent yields.

Synthesis and Catalytic Activity of Quaternary Ammonium Salts Containing gem-Dichlorocyclopropane and 1,3-Dioxolane Fragments

Abstract: Quaternary ammonium salts containing gem-dichlorocyclopropane and 1,3-dioxolane groups were synthesized in high yield. The reactions of dichlorocarbonation of styrene and O-alkylation of 2,2-dimethyl-4-hydroxymethyl-1,3-dioxolane in the presence of quaternary ammonium salts were studied. It was established that in the O-alkylation reaction, compounds containing cycloacetal and allyl moieties have the maximum efficiency in the series of catalysts studied. The structures of the isolated salts were proved by 1H and 13C NMR spectroscopy.

Condensation of 1,2,4-Butanetriol with Carbonyl Compounds and Reactions of Hydroxyalkyl-1,3-dioxacyclanes

A mixture of isomers of 2-(1,3-dioxolan-4-yl)ethanol and 1,3-dioxan-4-ylmethanol was prepared by reaction of 1,2,4-butanetriol with paraformaldehyde. This mixture was subjected to O-alkylation, O-acylation, condensation with phenyl isocyanate, and substitution of OH groups for Cl. The relative activity of acetone derivatives of glycerol and 1,2,4-butanetriol in reactions with allyl chloride and benzyl chloride was estimated.

Hybrid Fluorinated and Hydrogenated Double-Chain Surfactants for Handling Membrane Proteins

Two hybrid fluorinated double-chain surfactants with a diglucosylated polar head were synthesized. The apolar domain consists of a perfluorohexyl main chain and a butyl hydrogenated branch as a side chain. They were found to self-assemble into small micel

Selective functionalization of the primary hydroxy group in triols

A procedure was suggested for preparing functionally substituted 1,2-diols by O-alkylation of hydroxyalkyl-1,3-dioxacyclanes with alkyl halides, followed by acid hydrolysis. The conditions for selective cleavage of the ethers obtained were found. (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl benzoate under the conditions of acid deacetalization undergoes saponification of the ester group.

Discovery of lipids from B. longum subsp. infantis using whole cell MALDI analysis

Bifidobacteria are dominant members of the microbial community in the intestinal tract of infants, and studies have shown that glycolipids extracted from the cell surface of these bacteria elicit beneficial immune responses. Accordingly, the identification and structural characterization of glycolipids from the cell wall of bifidobacteria is the first step in correlating glycolipid structure with biological activity. Using whole cell MALDI as a screening tool, we herein present for the first time the identification and structural elucidation of the major polar lipids from Bifidobacterium longum subs. infantis. The lipids identified include an unprecedented plasmenyl cyclophosphatidic acid and a mixed acetal glycolipid, with the latter subsequently being isolated and found to suppress the innate immune response.

METHODS FOR THE SYNTHESIS OF PLASMALOGENS AND PLASMALOGEN DERIVATIVES, AND THERAPEUTIC USES THEREOF

A method for preparing plasmalogens and derivatives thereof represented by Formula B, wherein R1 and R2 are similar or different, derived from fatty acids; R3 is selected from hydrogen and small alkyl groups. The synthetic route involves production of novel cyclic plasmalogen precursors of Formula A and their conversion to plasmalogens and plasmalogen derivatives of Formula B. Also disclosed is the therapeutic use of plasmalogens and derivatives thereof as produced by the synthetic route of the present invention.

Model studies toward a synthesis of asperaculin A: Exploration of iterative intramolecular Pauson-Khand reaction based strategies to access the dioxa[5.5.5.6]fenestrane framework

A concise strategy, involving tandem intramolecular Pauson-Khand reactions (IPKRs) on a readily available ene-diyne precursor, to access the dioxa-fenestrane framework is delineated.