98760-27-1

Basic information

• Product Name: 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane
• Synonyms: 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane
• CAS NO: 98760-27-1
• Molecular Weight: 236.268
• Mol File: 98760-27-1.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane(98760-27-1)
• EPA Substance Registry System: 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane(98760-27-1)

Safety Data

• Hazardous Substances Data: 98760-27-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 93-97-0 benzoic acid anhydride 
• 65-85-0 benzoic acid 
• 93-58-3 benzoic acid methyl ester 
• 582-25-2 Potassium benzoate 
• 3376-59-8 2,3-dihydroxypropyl benzoate 
• 67-64-1 acetone 
• 4362-40-7 5-chloromethyl-2,2-dimethyl-1,3-dioxolane 
• 532-32-1 sodium benzoate 

Downstream Products

• 4421-23-2 4-allyloxymethyl-2,2-dimethyl-1,3-dioxolane 
• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 111467-66-4 (S)-(-)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl benzoate 
• 51432-60-1 (R)-(+)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl benzoate 
• 143919-90-8 2-benzoyloxymethyl-5-acethoxy-1,3-oxathiolane 
• 358348-70-6 cis/trans-2-benzoyloxymethyl-5-(cytosin-1'-yl)-1,3-oxathiolane 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 108636-60-8 3,4-cis-4-benzoyloxymethyl-3-benzyloxycarbonylamino-1-<(1S)-1-methoxycarbonyl-2-methylpropyl>-2-azetidinone 
• 918868-68-5 (+/-)-2-(mesyloxy)-3-[(4-methoxytrityl)oxy]propyl benzoate 
• 14347-78-5 1,2-O-isopropylidene-D-glycerol 
• 64904-47-8 2-benzoyloxyacetaldehyde 
• 3376-59-8 2,3-dihydroxypropyl benzoate 

Relevant articles and documents

3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS

Compounds of formula (I) wherein Het1, Het2, R1, R2 and R3 are as defined in the description. Medicaments.

Preparation method for emtricitabine isomer

The invention discloses a preparation method for an embritabine isomer. The preparation method comprises the following steps: with Solketal as a starting material, allowing the Solketal to undergo a six-step reaction of esterification, hydrolysis, oxidation, condensation cyclization, acetylation and glycosylation condensation so as to synthesize four mixture intermediates of emtricitabine; and splitting the four isomer intermediates into a cis-isomer mixture and a trans-isomer mixture through a chiral reagent. According to the invention, by adoption of a simple starting material, a mixture forsplitting key intermediates of four optical isomers of the emtricitabine is synthesized through the six-step reaction, and chiral acid is utilized to split the four isomers into a mixture of cis andtrans isomers, so the preparation method provided by the invention has the advantages of simple and convenient operation, high yield and high isomer chiral purity.

Utilization of hexabromoacetone for protection of alcohols and aldehydes and deprotection of acetals, ketals, and oximes under UV irradiation

Hexabromoacetone (HBA) was efficiently used for the protection of alcohols and aldehydes and deprotection of benzaldehyde dimethyl acetal, solketal, and other acetals and ketals. In only 10?min, the protection of glycerol yielded 90% of solketal and protection of benzaldehyde gave 95% of benzaldehyde dimethyl acetal. The deprotection of benzaldehyde dimethyl acetal under UV irradiation gave over 90% yield of benzaldehyde within 15?s using only 2.5?mol% of HBA. HBA was also successfully used for deoximation. Solvent was found to play an important role in the efficiency of HBA for these reactions.