186663-07-0

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 95-55-6 2-amino-phenol 
• 100-44-7 benzyl chloride 
• 186663-74-1 tert-butyl (2-hydroxyphenyl)carbamate 
• 100-39-0 benzyl bromide 

Downstream Products

• 20012-63-9 o-(benzyloxy)aniline 
• 727404-86-6 8-benzyloxy-3-methyl-2,3,4,9-tetrahydro-1H-β-carbolin-1-one 
• 265989-31-9 N-(2-(benzyloxy)phenyl)-4-methyl-3-oxopentanamide 
• 887355-33-1 4-methyl-3-oxo-N-(2-benzyloxyphenyl)-2-[1-phenyl-2-(4-fluorophenyl)-2-oxoethyl]pentanamide 
• 265989-39-7 (4R-cis)-1,1-dimethylethyl-6-[2-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-[(4-benzyloxyphenyl)carbonyl]-1H-pyrrol-yl]ethyl]-2,2-dimethyl-1,3-dioxane-4-acetate 
• 163217-74-1 o-Hydroxyatorvastatin lactone 
• 30914-95-5 2-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one 
• 247023-19-4 2-benzyloxy-phenylhydrazine 

Relevant academic research and scientific papers

Synthesis of aspidodispermine via pericyclic framework reconstruction

A divergent approach to the pyrroloquinoline scaffold as present in the class of Aspidosperma alkaloids was developed. As a case study, abundant and renewable nicotinic acid was transformed via pericyclic framework reconstruction into aspidodispermine, a unique member of pyrroloquinoline alkaloids. The sequence comprises a [2 + 2]-photocycloaddition, a Ramberg-B?cklund contraction, and a strain-promoted formal electrocyclic rearrangement of a bicyclo[2.2.0]hexene and is potentially extendable to pyrroloindole scaffolds as present in the ibophyllidine alkaloids.

An Expedient Synthesis of 2-Aryl-1,4-benzoxazin-3-ones via Tandem Anionic Cyclisation/Alkylation Reactions of N -Boc- O -benzyl-2-aminophenols

A one-pot, tandem anionic cyclization/alkylation reaction of N-Boc-O-benzylated-2-aminophenols to give 2-aryl-1,4-benzoxazin-3-ones is described. The Boc protecting group plays a crucial role in the process, as the tert-butoxide liberated in the cyclisati

IMPROVED PROCESS FOR THE PREPARATION OF [3R,5R]-2-FLUOROPHENYL-β,δ- DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(2-HYDROXYPHENYLAMINO)- CARBONYL]-1H-PYRROLE-1-HEPTANOIC ACID, SODIUM SALT

The present invention relates to an improved process for the preparation of [3R,5R]-2-fluorophenyl-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(2-hydroxyphenylamino)-carbonyl]-1H-pyrrole-1-heptanoic acid sodium salt compound of formula- 1 represented by the following structural formula:

Synthesis of 7-alkoxy/hydroxy-α-methyltryptamines

A simple method for the preparation of 7-alkoxy/hydroxy-α -methyl-DL-tryptamines is reported. The key steps of the synthesis are the Japp-Klingemann coupling of 2-piperidone-3-carboxylic acid 3 with diazonium salts 4, the Fischer-type cyclization of hydrazones 5 to β-carboline derivatives 6 and their hydrolysis to title compounds 8.