18672-03-2

Basic information

• Product Name: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE
• Synonyms: 5,6-DICHLORO-1H-BENZO[D]IMIDAZOL-2-AMINE;5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE;2-Amino-5,6-dichlorobenzimidazole;1H-Benzimidazol-2-amine, 5,6-dichloro-;2-Amino-5,6-dichloro-1H-benzimidazole
• CAS NO: 18672-03-2
• Molecular Formula: C₇H₅Cl₂N₃
• Molecular Weight: 202.04
• Product Categories: blocks;Imidazoles;pharmacetical
• Mol File: 18672-03-2.mol
• Article Data: 15

Chemical Properties

• Melting Point: 244-246℃
• Boiling Point: 435.4 °C at 760 mmHg
• Flash Point: 217.1 °C
• Appearance: /
• Density: 1.665 g/cm³
• Vapor Pressure: 8.78E-08mmHg at 25°C
• Refractive Index: 1.775
• Storage Temp.: 2-8°C(protect from light)
• PKA: 8.47±0.10(Predicted)
• CAS DataBase Reference: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE(18672-03-2)
• EPA Substance Registry System: 5,6-DICHLORO-1H-BENZIMIDAZOL-2-AMINE(18672-03-2)

Safety Data

• Hazardous Substances Data: 18672-03-2(Hazardous Substances Data)

Usage

Uses

2-Amino-5,6-dichlorobenzimidazole is used as pharmaceutical intermediate.

InChI:InChI=1/C7H5Cl2N3/c8-3-1-5-6(2-4(3)9)12-7(10)11-5/h1-2H,(H3,10,11,12)

Upstream product

• 934-32-7 1H-benzimidazol-2-amine 
• 5348-42-5 4,5-Dichloro-1,2-phenylenediamine 
• 506-68-3 bromocyane 
• 7440-44-0 pyrographite 
• 6641-64-1 4,5-dichloro-2-nitroaniline 

Downstream Products

• 1427319-80-9 (E)-N-benzylidene-6,7-dichloro-2-phenyl-1H-benzo[d]imidazo[1,2-a]imidazol-3-amine 

Relevant articles and documents

Cu-Catalyzed Synthesis of 3-Formyl Imidazo[1,2-a]pyridines and Imidazo[1,2-a]pyrimidines by Employing Ethyl Tertiary Amines as Carbon Sources

A highly efficient synthesis of 3-formyl imidazo[1,2-a]pyridine and imidazo[1,2-a]pyrimidine, under Cu-catalyzed aerobic oxidative conditions and by utilizing ethyl tertiary amines as carbon sources, is disclosed. A novel activation mode of ethyl tertiary amines in which simultaneous selective cleavage of C-C bond and C-N bond of ethyl group with molecular oxygen as terminal oxidant in this one-pot protocol is reported for the first time. This reaction features broad substrate scope, good functional group tolerance, as well as diversified and valuable products.

Catalyst-controlled chemoselective arylation of 2-aminobenzimidazoles

What N would you like? The chemoselective and complementary Pd- and Cu-catalyzed N-arylation of 2-aminobenzimidazoles is described. Selective N-arylation of the amino group was achieved with a Pd-catalyzed method, while selective N-arylation of azole nitrogen was achieved with a Cu-catalyzed procedure (see scheme). Copyright

JAK-2 MODULATORS AND METHODS OF USE

This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention