186792-78-9

Upstream product

• 98-88-4 benzoyl chloride 
• 6872-06-6 2-methyl indoline 
• 111457-18-2 N-(2-allyl-phenyl)-benzamide 
• 100-52-7 benzaldehyde 

Downstream Products

• 55-21-0 benzamide 
• 579-93-1 2-(Benzoylamino)benzoic Acid 
• 144-62-7 oxalic acid 
• 65-85-0 benzoic acid 
• 89-52-1 o-acetylamino-benzoic acid 

Relevant academic research and scientific papers

Carbon bridged bis-amide-based rare-earth amine compound and its preparation and with [...][...] synthesis reaction in the application of the

The invention discloses a carbon-bridged diacylamino rare earth amide with a general formula of {LLn[N(SiMe3)2]}2, wherein Ln is a rare earth metal selected from lanthanum, neodymium, samarium and yttrium, L represents a carbon-bridged diacylamino ligand, and n may be 1, 2 or 3 and can represent different ligands. The chemical structural formula of the carbon-bridged diacylamino rare earth amide differs with changes of the rare earth metal and the ligand. The invention targetedly discloses four chemical structural formulas of the rare earth amide as shown in the general formula. The carbon-bridged diacylamino rare earth amide provided by the invention is simple to synthesize, has definite structure and high yield and is easy to separate and purify. The invention also provides a preparation method for the rare earth amide and a method for applying the rare earth amide as a catalyst for catalysis of amidation of aldehyde and amine. The application method has the advantages of mild conditions, high activity, good selectivity, a wide substrate adaptation scope, a small catalyst amount and high product yield.

Synthesis and characterization of bridged bis(amidato) rare earth metal amides and their applications in C-N bond formation reactions

Based on three bisamide proligands H2Ln (n = 1-3) (H2L1 = [(Me3C6H2CONHCH2)2CH2], H2L2 = [(Me3C6H2CONHCH2)2C(CH3)2], H2L3 = [Me3C6H2CONH(CH2)2]2NCH3), eight bis(amidato) trivalent rare-earth metal amides {LnRE[N(TMS)2]}2 (n = 1, RE = La (1), Sm (2), Nd (3), Y (4); n = 2, RE = La (5), Nd (6); n = 3, RE = La (7), Nd (8); TMS = SiMe3) were successfully synthesized by treatment of H2Ln with RE[N(TMS)2]3 in a 1:1 molar ratio. Complexes 3, and 5-8 were characterized by single-crystal X-ray diffraction, and NMR characterization was carried out for the La complexes 1, 5, 7 and the Y complex 4. These complexes exhibited high catalytic activities in both the direct amidation of aldehydes and the addition of amines with carbodiimine. It was found that the bis(amidato) rare earth metal amides bearing different linkers have different effects on the transformations and lanthanum and neodymium complexes performed better than others.

N-tosyl-(S)-prolyl chloride in kinetic resolution of racemic heterocyclic amines

The kinetic resolution of racemic heterocyclic amines via acylation with N-tosyl-(S)-prolyl chloride was systematically investigated. It was established that racemic mixtures of aromatic amines could be resolved with high efficiency, while the acylation of 2- and 3-methylpiperidines occurred with low diastereoselectivity. A method for the preparation of enantiomerically pure (3R)-7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine was developed.

Decarboxylative acylation of indolines with α-keto acids under palladium catalysis: A facile strategy for the synthesis of 7-substituted indoles

Palladium-catalyzed decarboxylative acylation of highly substituted indolines with α-keto acids via C-H bond activation is described. This protocol provides efficient access to C7-carbonylated indoles known to have diverse biological profiles. This journal is

Synthesis of indolines and quinoline Via cyclization of N-arylsulfonyl-2-allylanilines catalyzed by bronsted acid

N-Arylsulfonyl-2-allylanilines underwent the intramolecular hydroamination to produce indolines or quinoline in the presence of catalytic amount of triflic acid with good yield. The scope of the reaction was extended to other N-protected aminoalkenes.

Microbiological Transformations Part 13. Microbiological Transformations of Derivatives of Indoline with the Fungus Cunninghamella elegans

The incubation of N-benzoylindoline and N-benzoyl-3-methylindoline with C. elegans resulted in reductive cleavage to produce the corresponding indoline and benzyl alcohol.N-Benzoyl-2-methylindoline and N-acetyl-2-methylindoline were hydroxylated at the benzylic position to produce a mixture of cis- and trans-substituted products.In contrast aromatic ring hydroxylation of N-acetyl-2-methylindoline occurred to give N-acetyl-5-hydroxy-2-methylindoline.Incubation of N-benzoyl-7-methylindoline also resulted in aromatic ring hydroxylation.