18703-72-5Relevant academic research and scientific papers
Preparation method of 2- (I)-3-methyl-benzoyl benzofuran (benzofuran) derivative
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Paragraph 0036-0039, (2019/11/18)
The invention discloses a preparation method of a 2-methyl-3-benzoylbenzofuran derivative. According to the preparation method, a 1-(phenylethynyl)-2-(ethylnenoxy)benzene substituendum is taken as rawmaterial, FeCl2 is taken as a catalyst, Phen is taken a
Lewis Acid-Catalyzed Synthesis of Benzofurans and 4,5,6,7-Tetrahydrobenzofurans from Acrolein Dimer and 1,3-Dicarbonyl Compounds
Huang, Wenbo,Xu, Jing,Liu, Changhui,Chen, Zhiyan,Gu, Yanlong
, p. 2941 - 2950 (2019/02/26)
2,3-Disubstituted benzofurans were synthesized from acrolein dimer and 1,3-dicarbonyl compounds by using N-bromosuccinimide as an oxidizing agent. The method was used to synthesize two commercial drug molecules, benzbromarone and amiodarone. The proposed mechanism of the reaction involves a N-bromosuccinimide (NBS)-assisted autotandem catalysis with Lewis acid catalyst. To proof the proposed mechanism, an intermediate was isolated successfully, which can be converted to 4,5,6,7-tetrahydrobenzofurans.
Synthesis of carbonylated heteroaromatic compounds: Via visible-light-driven intramolecular decarboxylative cyclization of o -alkynylated carboxylic acids
Gao, Fei,Wang, Jiu-Tao,Liu, Lin-Lin,Ma, Na,Yang, Chao,Gao, Yuan,Xia, Wujiong
, p. 8533 - 8536 (2017/08/04)
An efficient strategy for the easy access to carbonylated heteroaromatic compounds has been developed via a visible-light-promoted intramolecular decarboxylative cyclization reaction of o-alkynylated carboxylic acids. This method is characterized by its b
Gold(III)-catalyzed tandem reaction of O-arylhydroxylamines with 1,3-dicarbonyl compounds: Highly selective synthesis of 3-carbonylated benzofuran derivatives
Liu, Yunkui,Qian, Jianqiang,Lou, Shaojie,Xu, Zhenyuan
supporting information; experimental part, p. 6300 - 6303 (2010/11/18)
Figure presented. A highly regioselective protocol for the synthesis of 3-carbonylated benzofuran derivatives has been developed involving the gold(III)-catalyzed tandem condensation/rearrangement/cyclization reaction of O-arylhydroxylamines with 1,3-dicarbonyl compounds.
Cycloaddition of arynes with lodonium ylides: A mild and general route for the synthesis of benzofuran derivatives
Huang, Xiao-Cheng,Liu, Yi-Lin,Liang, Yun,Pi, Shao-Feng,Wang, Feng,Li, Jin-Heng
supporting information; experimental part, p. 1525 - 1528 (2009/04/07)
A mild and general cycloaddition of arynes with iodonium ylides protocol has been developed for the synthesis of benzofurans. In the presence of CsF, ortho-silyl aryltriflates were reacted with iodonium ylides smoothly at room temperature in moderate to good yields.
Selective Mono- and Polymethylene Homologations of Copper Reagents Using (Iodomethyl)zinc Iodide
Sidduri, AchyuthaRao,Rozema, Michael J.,Knochel, Paul
, p. 2694 - 2713 (2007/10/02)
A wide range of unsaturated aryl-, alkenyl-, alkynylcopper compounds can be selectively homologated by a methylene unit using (iodomethyl)zinc iodide or bis(iodomethyl)zinc.These reactions allow the generation of mixed allylic zinc-copper compounds which can be efficiently trapped with carbonyl compounds.An application to a general preparation of functionalized α-methylene-γ-butyrolactones is described.The homologation of alkynylcoppers with (iodomethyl)zinc iodide allows a one-pot preparation of propargylic copper reagents which in the presence of a carbonyl compound provide various homopropargylic alcohols in excellent yields.In the absence of an electrophile, a clean quadruple methylene homologation of alkynylcoppers occurs to furnish dienic copper reagents.The homologation of other types of copper reagents is also possible, and carbanions at the α-position to amines as well as homoenolates of aldehydes or ketones can also be prepared by this method.
Intramolecular Ketene Cycloadditions. Synthesis of Isoflavones and 3-Aroylbenzofurans
Brady, William T.,Gu, Yi-Qi
, p. 1353 - 1356 (2007/10/02)
The conversion of 2-(carboxyalkoxy)benzils to the corresponding phenoxyketenes to an intramolecular ketene cycloaddition to ultimately yield isoflavones and/or 3-aroylbenzofurans.The ketenes may be generated by the classical dehydrochlorination of the acid chloride or by using Perkin reaction conditions, sodium acetate in refluxing acetic anhydride.The initial cycloaddition products are the corresponding β-lactones, which may decarboxylate to the isolated isoflavones and/or 2-aroylbenzofurans.The product distributions are dependent upon the substitution pattern in the orginal benzil acids.
