1871-96-1Relevant articles and documents
New synthetic technology for the mild and selective one-carbon homologation of hindered aldehydes in the presence of ketones
Nicolaou,Vassilikogiannakis, Georgios,Kranich, Remo,Baran, Phil S.,Zhong, Yong-Li,Natarajan, Swaminathan
, p. 1895 - 1898 (2000)
(Formula presented) A selective, mild, and highly efficient method has been uncovered during the total synthesis of the CP molecules to accomplish the one-carbon homologation of sterically hindered aldehydes in the presence of acid- and base-labile moieties, Michael acceptors, and even other carbonyl groups such as reactive and epimerizable ketones. Mechanistic studies have revealed a neutral reagent for the rapid collapse of cyanohydrins to ketones.
Corresponding amine nitrile and method of manufacturing thereof (by machine translation)
-
Paragraph 0136; 0137; 0140, (2018/07/15)
The present invention relates to a nitrile manufacturing method, which has characteristics of significantly-reduced ammonia source consumption, low environmental pressure, low energy consumption, low production cost, high nitrile purity, high nitrile yield and the like compared with the method in the prior art, wherein nitrile having a complicated structure can be obtained through the method. The present invention further relates to a method for producing a corresponding amine from the nitrile.
Corresponding amine nitrile and method of manufacturing thereof
-
Paragraph 0137; 0138; 0139; 0140; 0141, (2018/07/15)
The invention relates to a preparation method of nitrile. Compared with the prior art, the preparation method has the characteristics of obvious reduction of the usage amount of ammonia sources, low environmental pressure, low energy consumption, low production cost, high purity and yields of nitrile products, and the like, and can be used for obtaining nitrile with a more complex structure. The invention also relates to a method for preparing corresponding amine with nitrile.
