1873-54-7

Basic information

• Product Name: 3-Ethylquinoline
• Synonyms: 3-ETHYL QUINOLINE;β-Ethylquinoline
• CAS NO: 1873-54-7
• Molecular Formula: C₁₁H₁₁N
• Molecular Weight: 157.21
• EINECS: -0
• Product Categories: Quinoline&Isoquinoline
• Mol File: 1873-54-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 51.53°C (estimate)
• Boiling Point: 266.88°C (estimate)
• Flash Point: 107.982 °C
• Appearance: /
• Density: 1.0508
• Vapor Pressure: 0.0158mmHg at 25°C
• Refractive Index: 1.6160
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-Ethylquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethylquinoline(1873-54-7)
• EPA Substance Registry System: 3-Ethylquinoline(1873-54-7)

Safety Data

• Hazardous Substances Data: 1873-54-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 20, p. 1091, 1990 DOI: 10.1080/00397919008052815

InChI:InChI=1/C11H11N/c1-2-9-7-10-5-3-4-6-11(10)12-8-9/h3-8H,2H2,1H3

Upstream product

• 67525-28-4 2-chloro-3-ethylquinoline 
• 78593-40-5 3-ethynylquinoline 
• 33021-53-3 1-quinolin-3-yl-ethanone 
• 3586-58-1 2-methylenebutyric acid 
• 271-58-9 anthranil 
• 3238-55-9 2-propionylpyridine 
• 5332-24-1 3-bromoquinoline 
• 5344-90-1 2-Aminobenzyl alcohol 
• 71-36-3 butan-1-ol 
• 557-20-0 diethylzinc 
• 97-94-9 triethyl borane 
• 123-72-8 butyraldehyde 
• 1088979-58-1 [1-(2-(N-methyl-N-p-toluenesulfonylamino)benzoyl)-1-propylidene](triphenyl)phosphorane 
• 56640-46-1 1-(phenylmethyl)butanoic acid 

Downstream Products

• 6480-68-8 quinoline-3-carboxylic acid 

Relevant articles and documents

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Hydrazine Hydrate Accelerates Neocuproine–Copper Complex Generation and Utilization in Alkyne Reduction, a Significant Supplement Method for Catalytic Hydrogenation

Diimine (HN═NH) is a strong reducing agent, but the efficiency of diimine oxidized from hydrazine hydrate or its derivatives is still not good enough. Herein, we report an in situ neocuproine–copper complex formation method. The redox potential of this complex enable it can serve as an ideal redox catalyst in the synthesis of diimine by oxidation of hydrazine hydrate, and we successfully applied this technique in the reduction of alkynes. This reduction method displays a broad functional group tolerance and substrate adaptability as well as the advantages of safety and high efficiency. Especially, nitro, benzyl, boc, and sulfur containing alkynes can be reduced to the corresponding alkanes directly, which provides a useful complementary method to traditional catalytic hydrogenation. Besides, we applied this method in the preparation of the Alzheimer’s disease drug CT-1812 and studied the mechanism.

Rh-Catalyzed C-H Amination/Annulation of Acrylic Acids and Anthranils by Using -COOH as a Deciduous Directing Group: An Access to Diverse Quinolines

A method for the synthesis of diverse polysubstituted quinolines from readily available acrylic acids and anthranils has been developed. The weakly coordinating -COOH directing group, which can be tracelessly removed in the cascade cyclization, is essential for this reaction. Diverse polysubstituted quinolines were obtained under mild reaction conditions with simple H2O and CO2 as byproducts. More importantly, 1,2,3,4-tetrahydroacridine, which is the core skeleton of tacrine (an Alzheimer's disease drug), was conveniently synthesized.

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.