33021-53-3

Basic information

• Product Name: 1-QUINOLIN-3-YLETHANONE
• Synonyms: 1-QUINOLIN-3-YLETHANONE;3-Acetylquinoline;1-(3-quinolinyl)Ethanone
• CAS NO: 33021-53-3
• Molecular Formula: C₁₁H₉NO
• Molecular Weight: 171.19526
• Mol File: 33021-53-3.mol
• Article Data: 29

Chemical Properties

• Melting Point: 97-99℃
• Boiling Point: 139℃/4mm
• Appearance: /
• Density: 1.154±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.28±0.11(Predicted)
• CAS DataBase Reference: 1-QUINOLIN-3-YLETHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-QUINOLIN-3-YLETHANONE(33021-53-3)
• EPA Substance Registry System: 1-QUINOLIN-3-YLETHANONE(33021-53-3)

Safety Data

• Hazardous Substances Data: 33021-53-3(Hazardous Substances Data)

Usage

General Description

1-Quinolin-3-ylethanone, also known as isoquinoline-3-carbaldehyde, is a compound with the molecular formula C10H9NO. It is a pale yellow to white solid with a strong odor and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical is also used as an intermediate in the production of dyes, flavors, and fragrance compounds. Additionally, it has been studied for its potential antimicrobial and antifungal properties. 1-Quinolin-3-ylethanone is considered to be a hazardous substance and should be handled with care in a controlled laboratory environment.

Upstream product

• 78593-40-5 3-ethynylquinoline 
• 5332-24-1 3-bromoquinoline 
• 78191-00-1 N-Methoxy-N-methylacetamide 
• 74-88-4 methyl iodide 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 201230-82-2 carbon monoxide 
• 917-54-4 methyllithium 
• 477723-56-1 3-(1-Butoxy-vinyl)-quinoline 
• 78-94-4 methyl vinyl ketone 
• 529-23-7 o-aminobenzaldehyde 
• 580-17-6 3-aminoquinoline 
• 431-03-8 dimethylglyoxal 
• 271-58-9 anthranil 

Downstream Products

• 130728-61-9 3-acetylquinoline phenylhydrazone 
• 33054-18-1 ethyl 2-(quinolin-3-yl) acetate 
• 6480-68-8 quinoline-3-carboxylic acid 
• 1424035-67-5 (S)-3-(1-phenylethyl)quinoline 
• 1873-54-7 3-ethyl quinoline 

Relevant articles and documents

A stereodynamic and redox-switchable encapsulation-complex containing a copper ion held by a tris-quinolinyl basket

We investigated the coordination of Cu(i)/Cu(ii) ions to chiral basket (S3)-1. The results of both experimental and computational studies suggest the formation of a copper redox-switchable system capable of entrapping CH3CN.

Photoinduced Acetylation of Anilines under Aqueous and Catalyst-Free Conditions

A green and efficient visible-light induced functionalization of anilines under mild conditions has been reported. Utilizing nontoxic, cost-effective, and water-soluble diacetyl as photosensitizer and acetylating reagent, and water as the solvent, a variety of anilines were converted into the corresponding aryl ketones, iodides, and bromides. With advantages of environmentally friendly conditions, simple operation, broad substrate scope, and functional group tolerance, this reaction represents a valuable method in organic synthesis.

Palladium-catalyzed acetylation of arylbromides

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Highly chemoselective deoxygenation of N-heterocyclic: N -oxides under transition metal-free conditions

Because their site-selective C-H functionalizations are now considered one of the most useful tools for synthesizing various N-heterocyclic compounds, the highly chemoselective deoxygenation of densely functionalized N-heterocyclic N-oxides has received much attention from the synthetic chemistry community. Here, we provide a protocol for the highly chemoselective deoxygenation of various functionalized N-oxides under visible light-mediated photoredox conditions with Na2-eosin Y as an organophotocatalyst. Mechanistic studies imply that the excited state of the organophotocatalyst is reductively quenched by Hantzsch esters. This operationally simple technique tolerates a wide range of functional groups and allows high-yield, multigram-scale deoxygenation. This journal is