187394-38-3Relevant academic research and scientific papers
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji
, p. 4900 - 4911 (2005)
To shed light on the structure-activity relationship, various soyasapogenol B derivatives were synthesized and evaluated for preventive effects on liver injury in the concanavalin A (Con A)-induced hepatitis model in mice. Con A injection into mice induces some pathophysiology of human liver disease such as autoimmune or viral hepatitis. Two hydroxyl groups on the A ring of soyasapogenol B are required for amelioration of liver damage. Modification of the C-22 hydroxyl moiety with an acyloxy or alkyloxy group, or removal of the hydroxyl group, resulted in a greatly enhanced percentage of alleviation. Among the series of soyasapogenol B derivatives examined, six compounds exhibited preventive effects on liver damage.
Oleanene-type triterpene glycosides from puerariae radix. III. Three new saponins from Pueraria thomsonii
Arao, Tomonori,Idzu, Tomoko,Kinjo, Junei,Nohara, Toshihiro,Isobe, Ryuichi
, p. 1970 - 1972 (1996)
From the root of Pueraria thomsonii (Leguminosae), three new oleanane- type triterpene glycosides, named kudzusaponin B1, acetyl-kaikasaponin III and acetyl-soyasaponin I were isolated, together with soyasaponin I (4) and subproside V (5). Thei
Synthesis and hepatoprotective effects of soyasapogenol B derivatives
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji,Omoto, Shoji
, p. 85 - 88 (2007/10/03)
Derivatives of soyasapogenol B (1), which is the aglycon moiety of soyasaponins from soybean, were synthesized and evaluated for their hepatoprotective effects in vitro.
