186415-74-7Relevant academic research and scientific papers
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji
, p. 4900 - 4911 (2007/10/03)
To shed light on the structure-activity relationship, various soyasapogenol B derivatives were synthesized and evaluated for preventive effects on liver injury in the concanavalin A (Con A)-induced hepatitis model in mice. Con A injection into mice induces some pathophysiology of human liver disease such as autoimmune or viral hepatitis. Two hydroxyl groups on the A ring of soyasapogenol B are required for amelioration of liver damage. Modification of the C-22 hydroxyl moiety with an acyloxy or alkyloxy group, or removal of the hydroxyl group, resulted in a greatly enhanced percentage of alleviation. Among the series of soyasapogenol B derivatives examined, six compounds exhibited preventive effects on liver damage.
Synthesis and hepatoprotective effects of soyasapogenol B derivatives
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji,Omoto, Shoji
, p. 85 - 88 (2007/10/03)
Derivatives of soyasapogenol B (1), which is the aglycon moiety of soyasaponins from soybean, were synthesized and evaluated for their hepatoprotective effects in vitro.
Medicinal foodstuffs. VI. Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaris L.: Chemical structures of sandosaponins A and B
Yoshikawa, Masayuki,Shimada, Hiromi,Komatsu, Hajime,Sakurama, Tetsuo,Nishida, Norihisa,Yamahara, Johji,Shimoda, Hiroshi,Matsuda, Hisashi,Tani, Tadato
, p. 877 - 882 (2007/10/03)
Two new olean-12-ene-type triterpene oligoglycosides, named sandsaponins A and B, were isolated from kidney bean, the seed of Phaseoulus vulgaris L., together with three known saponins, soyasaponins I and V and dehydrosoyasaponin I. The structures of sand
