186415-73-6Relevant articles and documents
Preventive effects of soyasapogenol B derivatives on liver injury in a concanavalin A-induced hepatitis model
Sasaki, Kazue,Minowa, Nobuto,Kuzuhara, Hiroyuki,Nishiyama, Shoji
, p. 4900 - 4911 (2007/10/03)
To shed light on the structure-activity relationship, various soyasapogenol B derivatives were synthesized and evaluated for preventive effects on liver injury in the concanavalin A (Con A)-induced hepatitis model in mice. Con A injection into mice induces some pathophysiology of human liver disease such as autoimmune or viral hepatitis. Two hydroxyl groups on the A ring of soyasapogenol B are required for amelioration of liver damage. Modification of the C-22 hydroxyl moiety with an acyloxy or alkyloxy group, or removal of the hydroxyl group, resulted in a greatly enhanced percentage of alleviation. Among the series of soyasapogenol B derivatives examined, six compounds exhibited preventive effects on liver damage.
Medicinal foodstuffs. VI. Histamine release inhibitors from kidney bean, the seeds of Phaseolus vulgaris L.: Chemical structures of sandosaponins A and B
Yoshikawa, Masayuki,Shimada, Hiromi,Komatsu, Hajime,Sakurama, Tetsuo,Nishida, Norihisa,Yamahara, Johji,Shimoda, Hiroshi,Matsuda, Hisashi,Tani, Tadato
, p. 877 - 882 (2007/10/03)
Two new olean-12-ene-type triterpene oligoglycosides, named sandsaponins A and B, were isolated from kidney bean, the seed of Phaseoulus vulgaris L., together with three known saponins, soyasaponins I and V and dehydrosoyasaponin I. The structures of sand