18753-56-5

Basic information

• Product Name: 5-Benzyl-3-phenylisoxazole
• Synonyms: 5-Benzyl-3-phenylisoxazole
• CAS NO: 18753-56-5
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 0
• Mol File: 18753-56-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Benzyl-3-phenylisoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzyl-3-phenylisoxazole(18753-56-5)
• EPA Substance Registry System: 5-Benzyl-3-phenylisoxazole(18753-56-5)

Safety Data

• Hazardous Substances Data: 18753-56-5(Hazardous Substances Data)

Upstream product

• 10147-11-2 propargyl benzene 
• 932-90-1 Benzaldoxime 
• 21772-11-2 1,4-diphenylbutan-3-yn-2-one 
• 536-74-3 phenylacetylene 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 103-79-7 1-phenyl-acetone 
• 698-16-8 benzohydroximoyl chloride 
• 52201-28-2 1-(1-methyl-2-phenyl ethenyl)-pyrrolidine 
• 98-86-2 acetophenone 
• 101-97-3 Ethyl 2-phenylethanoate 
• 103-82-2 phenylacetic acid 
• 10341-75-0 (E)-1-phenylethanone oxime 
• 95092-10-7 N-methoxy-N-methyl-2-phenylacetamide 
• 873-67-6 benzonitrile oxide 

Downstream Products

• 1373038-58-4 C₁₆H₁₄N₂O₃S 
• 1373038-62-0 C₁₆H₁₂ClNO₃S 

Relevant articles and documents

Green preparation method of isoxazole compound participating in water-soluble vitamin E

The invention provides a green synthesis method of an isoxazole compound represented by the formula (III), wherein the aldehyde oxime compound represented by the formula (I) is a substrate and is in an aqueous solution of a surfactant with a mass concentration 1 wt % - 5 wt % in N - chlorosuccinimide. The alkyne compound represented by the formula (II) is reacted 6 - 16h at room temperature under the common action of the basic substance, and the resulting reaction solution is post-treated to obtain the isoxazole compound represented by the formula (III). Water serves as a reaction solvent, the use amount of the organic solvent is reduced, and zero emission of the solvent is realized.

Synthesis of 3,5-disubstituted isoxazoles via cope-type hydroamination of 1,3-dialkynes

An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.

METHODS FOR THE SYNTHESIS OF HETEROAROMATIC COMPOUNDS

Methods of making heteroaromatic compounds comprising a 5- membered ring, and dihydro forms thereof, by a metal catalysed 5-endo-cyclisation of alkynes (acetylenes) are disclosed. The methods involve the use of a catalyst comprising a silver salt, more preferably a silver (I) salt, which is employed as a heterogeneous catalyst for the cyclisation reaction. The methods can produce different types of heteroaromatic compounds and are capable of producing highly substituted products, i.e. products in which the 5-membered ring is disubstituted, trisubstituted or, with further simple reactions, tetrasubstituted. The methods described herein generally the advantages that they use conditions and reagents that are benign, cheap and flexible and amenable to scale up, and in which the only by-product is water.