18808-85-0

Basic information

• Product Name: 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE
• Synonyms: 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE;4-(4-METHOXY-BENZYLIDENE)-5-METHYL-2-PHENYL-2,4-DIHYDRO-PYRAZOL-3-ONE
• CAS NO: 18808-85-0
• Molecular Formula: C₁₈H₁₆N₂O₂
• Molecular Weight: 292.33
• Mol File: 18808-85-0.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE(18808-85-0)
• EPA Substance Registry System: 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE(18808-85-0)

Safety Data

• Hazardous Substances Data: 18808-85-0(Hazardous Substances Data)

Usage

General Description

The chemical 4-((4-methoxyphenyl)methylene)-3-methyl-1-phenyl-2-pyrazolin-5-one, also known as Methyl 4-((4-methoxyphenyl)methylene)-3-methyl-1-phenyl-2-pyrazoline-5-one, is a yellow to orange solid compound. It is a pyrazolone derivative with potential anti-inflammatory and analgesic properties. 4-((4-METHOXYPHENYL)METHYLENE)-3-METHYL-1-PHENYL-2-PYRAZOLIN-5-ONE has been studied for its potential use in nonsteroidal anti-inflammatory drugs (NSAIDs) due to its ability to inhibit prostaglandin synthesis and reduce inflammation and pain. It has also been investigated for its potential applications in various pharmaceutical and medicinal chemistry research.

Upstream product

• 62-53-3 aniline 
• 89-25-8 edaravone 
• 105-13-5 4-Methoxybenzyl alcohol 
• 100-63-0 phenylhydrazine 
• 836-41-9 p-methoxybenzylidene-phenylamine 
• 942-32-5 5-methyl-2-phenyl-2H-pyrazol-3-ol 
• 76086-81-2 4-[(4-Methoxy-phenyl)-phenylamino-methyl]-5-methyl-2-phenyl-2,4-dihydro-pyrazol-3-one 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 53316-60-2 6-amino-4-(4-methoxyphenyl)-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 
• 76794-77-9 4-3-methyl-1-phenyl-2-pyrazolin-5-one 
• 1383625-38-4 4-(4-methoxyphenyl)-3,5-dimethyl-7-phenyl-4a,7-dihydro-4H-pyrazolo [4',3':5,6]pyrido[3,2-d]isoxazole 
• 1422554-88-8 C₂₈H₂₄N₄O₃S 

Relevant articles and documents

Ionic liquid-mediated facile synthesis of novel spiroheterobicyclic rings as potential antifungal and antibacterial drugs

A pseudo four-component reaction of urea or thiourea, diverse aryl aldehydes, and 3-methyl-1-phenyl-2-pyrazolin-5-one in ionic liquids yields novel azaspiro[4.5]decene derivatives. However, the corresponding reaction in volatile organic solvents gives Kno

Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[ c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

An enantioselective synthesis of spiropyrazolone-fused cyclopenta[c]chromen-4-ones is demonstrated via a (3+2) cycloaddition reaction. The reactions of 3-homoacylcoumarins and α,β-unsaturated pyrazolones in the presence of the cinchona-alkaloid derived hy

Enantio- and Diastereoselective Synthesis of β-Aryl-β-pyrazolyl α-Amino Acid Esters via Copper-Catalyzed Reaction of Azomethine Ylides with Benzylidenepyrazolones

A fully stereoselective synthesis of unnatural chiral β-aryl-β-pyrazolyl α-amino acid esters via copper-catalyzed addition reactions of azomethine ylides with benzylidenepyrazolones bearing two contiguous stereogenic centers was developed. A 1H-pyrazol-5-ol was introduced by the aromatization of 3H-pyrazol-3-one in the reaction. The transformation operated at room temperature and afforded β-1H-pyrazol-5-ol-α-amino esters in high yields with good to excellent levels of diastereo- and enantioselectivity.