188434-69-7

Upstream product

• 108-05-4 vinyl acetate 
• 108-24-7 acetic anhydride 
• 150338-78-6 (1S,4R)-cis-1-benzyloxycyclopent-2-en-4-ol 
• 183612-91-1 (+/-)-4-benzyloxy-2-cyclopentenone 
• 98-00-0 (2-furyl)methyl alcohol 
• 60410-16-4 (1R,4S)-4-hydroxy-2-cyclopentene-1-yl acetate 
• 100-39-0 benzyl bromide 
• 59995-47-0 4-Hydroxycyclopent-2-enone 

Downstream Products

• 866551-95-3 C₂₀H₂₇NO₇ 
• 783345-25-5 ((1R,5S)-5-Benzyloxy-cyclopent-2-enyl)-fluoro-acetic acid tert-butyl ester 
• 783345-23-3 ((1R,5S)-5-Benzyloxy-cyclopent-2-enyl)-acetic acid tert-butyl ester 
• 783345-22-2 ((1R,5S)-5-Benzyloxy-cyclopent-2-enyl)-acetic acid 

Relevant academic research and scientific papers

Stereoselective Synthesis for Potential Isomers of Ticagrelor Key Starting Material

Tartrate salt of carbocyclic amine 2 is one of the key starting materials for the synthesis of Ticagrelor 1. During the synthesis of 1, the isomers of 2 also need to be considered as potential impurities and characterized before establishing the specification of product. In the present work, detailed study has been carried out to synthesize the related substances of 2, and their structure characterization has been discussed.

Enantioselective syntheses of bicyclo[3.1.0]hexane carboxylic acid derivatives by intramolecular cyclopropanation

The title compounds serve as intermediates for the synthesis of mGluR agonists, which are useful for the treatment of CNS-related disorders. Enantioselective syntheses of bicyclo[3.1.0]hexane carboxylic acid derivatives are described. The syntheses were achieved by an intramolecular cyclopropanation as the key step, starting from enantiomerically pure starting materials that are commercially available.

The preparation of optically active 2-cyclopenten-1,4-diol derivatives from furfuryl alcohol

The preparation and enzymatic resolution of several cis-mono-4-O-protected-2-cyclopenten-1,4-diols are described. The process starts with inexpensive furfuryl alcohol and lends itself to the preparation of multigram quantities of various protected, optically active 2-cyclopenten-1,4-diol derivatives. Stereoselective reduction of 4-O-protected-2-cyclopentenone to the cis-mono-O-protected-2-cyclopenten-1,4-diol using LiAlH4/LiI or Red-Al/NaI is described. Subsequent pancreatin-promoted, stereoselective acylation was conducted on these cis-(+/-)-mono-O-protected-cyclopenten-1,4-diols to afford the corresponding alcohols and acetates in moderate to excellent enantioselectivities.