797750-44-8

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 5382-16-1 4-HYDROXYPIPERIDINE 
• 557-21-1 dicyanozinc 
• 226398-62-5 4-(4-bromobenzenesulfonyl)piperidine-1-carboxylic acid tert-butyl ester 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 557-21-1 zinc(II) cyanide 
• 188527-03-9 4-(4-bromophenylsulfanyl)piperidine-1-carboxylic acid tert-butyl ester 
• 106-53-6 para-bromobenzenethiol 

Downstream Products

• 797750-45-9 N-BOC 4-(4-fluoropiperidin-4-ylsulfonyl)benzonitrile 
• 1450723-99-5 C₁₂H₁₄N₂O₂S 
• 1450724-00-1 4-(1-acetylpiperidine-4-sulfonyl)benzonitrile 
• 1450724-01-2 C₁₅H₁₈N₂O₃S 
• 1450724-04-5 C₁₅H₁₈N₂O₃S 
• 1450724-05-6 4-[1-(tetrahydropyran-4-yl)piperidine-4-sulfonyl]benzonitrile 
• 1450724-02-3 C₁₃H₁₆N₂O₂S 
• 1450724-03-4 C₁₅H₂₀N₂O₂S 
• 1450723-87-1 C₁₃H₂₀N₂O₂S 
• 1450723-88-2 C₁₅H₂₄N₂O₂S 
• 1450723-34-8 N-[[4-(4,4-difluorocyclohexyl)sulfonylphenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 
• 1450724-22-7 C₂₀H₂₃N₃O₆S 
• 1450724-23-8 C₂₂H₂₇N₃O₆S 
• 1450723-38-2 N-[[4-[(1-acetyl-4-piperidyl)sulfonyl]phenyl]methyl]-1,3-dihydropyrrolo[3,4-c]pyridine-2-carboxamide 

Relevant academic research and scientific papers

AMIDO-BENZYL SULFONE AND SULFOXIDE DERIVATIVES

The present invention relates to certain amido-benzyl sulfoxide and sulfone compounds, pharmaceutical compositions comprising such compounds, and methods of treatment using such compounds.

Identification of 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT)

Potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitors containing 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived ureas were identified using structure-based design techniques. The new compounds displayed improved aqueous solubilities, determined using a high-throughput solubility assessment, relative to previously disclosed urea and amide-containing NAMPT inhibitors. An optimized 2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-derived compound exhibited potent anti-NAMPT activity (18; BC NAMPT IC50 = 11 nM; PC-3 antiproliferative IC50 = 36 nM), satisfactory mouse PK properties, and was efficacious in a PC-3 mouse xenograft model. The crystal structure of another optimized compound (29; NAMPT IC50 = 10 nM; A2780 antiproliferative IC50 = 7 nM) in complex with the NAMPT protein was also determined.

4-ARYLSULPHONYLPIPERIDINE DERIVATIVES FOR ANTAGONISM OF THE 5-HT2A RECEPTOR

Compounds of formula (I): are selective antagonists of the 5-HT2A receptor, and hence are useful in treatment of adverse conditions at the central nervous system, such as sleep disorders and schizophrenia.