1888-33-1

Basic information

• Product Name: N-(4-Methylphenyl)sulfonylacetamide
• Synonyms: N-ACETYL-P-TOLUENE SULFONAMIDE;N-ACETYL-4-TOLUENE SULFONAMIDE;N-(4-METHYLPHENYL)SULFONYLACETAMIDE;N-ACETYL-O,P-TOLUENESULFONAMIDE;N-(4-methylphenyl)sulfonylethanamide
• CAS NO: 1888-33-1
• Molecular Formula: C₉H₁₁NO₃S
• Molecular Weight: 213.25
• Mol File: 1888-33-1.mol
• Article Data: 35

Chemical Properties

• Melting Point: 140 °C
• Appearance: /
• Density: 1.254 g/cm³
• Refractive Index: 1.538
• CAS DataBase Reference: N-(4-Methylphenyl)sulfonylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methylphenyl)sulfonylacetamide(1888-33-1)
• EPA Substance Registry System: N-(4-Methylphenyl)sulfonylacetamide(1888-33-1)

Safety Data

• Hazardous Substances Data: 1888-33-1(Hazardous Substances Data)

Usage

General Description

N-(4-Methylphenyl)sulfonylacetamide is a chemical compound with the molecular formula C10H13NO3S. It is an organic compound that contains a sulfonyl functional group and an acetamide group. N-(4-Methylphenyl)sulfonylacetamide is commonly used as a building block in the synthesis of pharmaceuticals and organic molecules. N-(4-Methylphenyl)sulfonylacetamide has several potential applications in the field of medicinal chemistry, particularly in the development of new drugs for various therapeutic areas. Its chemical structure and properties make it a versatile starting material for the creation of novel compounds with potential biological activity.

InChI:InChI=1/C9H11NO3S/c1-7-3-5-9(6-4-7)14(12,13)10-8(2)11/h3-6H,1-2H3,(H,10,11)

Upstream product

• 4083-64-1 Tosyl isocyanate 
• 64-19-7 acetic acid 
• 70-55-3 toluene-4-sulfonamide 
• 75-36-5 acetyl chloride 
• 463-51-4 Ketene 
• 1363906-80-2 1-acetyl-2,3,4,6,7,8-hexahydropyrrolo[1,2-a]pyrimidinium tetraphenylborate 
• 86328-84-9 4-methyl-N-(naphthalen-1-ylmethyl)benzenesulfonamide 
• 10504-98-0 N-(4-chlorobenzyl)-p-toluenesulfonamide 
• 1022339-31-6 N-[(4-tert-butylphenyl)methyl]-4-methylbenzenesulfonamide 
• 10504-92-4 N-p-xylyl-p-toluenesulfonamide 
• 121618-47-1 N-benzyl-N-tosylacetamide 
• 1058-14-6 N-p-tolylsulfonylphosphine imide 
• 941-55-9 4-toluenesulfonyl azide 
• 507-09-5 tiolacetic acid 

Downstream Products

• 711-79-5 1-hydroxy-2-acetonaphthone 
• 575-36-0 1-acetamidonaphthalene 
• 103-89-9 4-Methylacetanilide 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 89-52-1 o-acetylamino-benzoic acid 
• 2719-05-3 N,N’-(methylenebis(4,1-phenylene))diacetamide 
• 103-84-4 Acetanilid 
• 579-10-2 N-acetyl-N-methylaniline 
• 588-46-5 N-(phenylmethyl)acetamide 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 
• 104496-43-7 N,N'-diacetyl-N,N'ditosyl-α,α'-p-xylenediamine 
• 960161-59-5 N-(4-methylbenzenesulfonyl)imidoylacetic acid (diacetyl)methyl ester 
• 960161-57-3 N-(4-methylbenzenesulfonyl)imidoylacetic acid (acetylethoxycarbonyl)methyl ester 
• 960161-55-1 N-(4-methylbenzenesulfonyl)imidoylacetic acid (dimethoxycarbonyl)methyl ester 

Relevant articles and documents

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

The chemoselective cleavage of C-N bonds of amides, sulfonamides, and acylsulfonamides by aluminum halides is described. AlCl3and AlI3display complementary reactivities toward N-alkyl and N-acyl moieties. N-Alkylacylsulfonamides, sec

Self-Promoted Glycosylation for the Synthesis of β-N-Glycosyl Sulfonyl Amides

N-Glycosyl N-sulfonyl amides have been synthesized by a self-promoted glycosylation, i. e. without any catalysts, promotors or additives. When the reactions were carried out at lower temperatures a mixture of N- and O-glycosides were observed, where the latter rearranged to give the β-N-glycosides at elevated temperatures. By this method sulfonylated asparagine derivatives can be selectively β-glycosylated in high yields by trichloroacetimidate glycosyl donors of different reactivity including protected glucosamine derivatives. The chemoselectivity in the glycosylations as well as the rearrangements from O-glycosides to β-N-glycosides gives information of the glycosylation mechanism. This method gives access to glycosyl sulfonyl amides under mild conditions.

Rhodium-catalyzed direct C-H bond alkynylation of aryl sulfonamides with bromoalkynes

Herein we report a novel rhodium-catalyzed ortho-mono-alkynylation of aryl sulfonamides. The reactions of N-tosylacetamides with triisopropylsilyl (TIPS)-substituted bromoalkyne are catalyzed by a [(Cp?RhCl2)2] complex without cyclization, forming ortho-(