189177-71-7Relevant academic research and scientific papers
Design, synthesis, crystal structure and fungicidal activity of (E)-5-(methoxyimino)-3,5-dihydrobenzo [e] [1,2]oxazepin-4(1 H)-one analogues
Yang, Dongyan,Wan, Chuan,He, Mengmeng,Che, Chuanliang,Xiao, Yumei,Fu, Bin,Qin, Zhaohai
, p. 1007 - 1014 (2017)
A practical method of four-step synthesis towards novel (E)-5-(methoxyimino)-3,5-dihydrobenzo[e][1,2]oxazepin-4(1H)-one antifungals is presented, where a commercially available pesticide and pharmacology intermediate, (E)-methyl 2-(2-(bromomethyl)phenyl)-
USE OF STROBILURIN TYPE COMPOUNDS FOR COMBATING PHYTOPATHOGENIC FUNGI CONTAINING AN AMINO ACID SUBSTITUTION F129L IN THE MITOCHONDRIAL CYTOCHROME B PROTEIN CONFERRING RESISTANCE TO QO INHIBITORS V
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Page/Page column 37-38, (2021/12/31)
The present invention relates to the use of strobilurin-like compounds of formula I and N-oxides and salts thereof to fight against phytopathogenic fungi, containing a substitution of amino acids F129L in the mitochondrial cytochrome b protein (also calle
Correction: Design, synthesis, crystal structure and fungicidal activity of (: E)-5-(methoxyimino)-3,5-dihydrobenzo [e] [1,2]oxazepin-4(1 H)-one analogues (MedChemComm (2017) 8 (1007-1014) DOI: 10.1039/C7MD00025A)
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, p. 1366 - 1366 (2017/07/07)
Unfortunately, Scheme 2 showed errors in the structures and substituents. The corrected scheme is shown below: (Formula Presented). The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
Stereoselective synthesis and antifungal activities of (E)-α- (methoxyimino)benzeneacetate derivatives containing 1,3,5-substituted pyrazole ring
Li, Yan,Zhang, Hong-Quan,Liu, Jie,Yang, Xiang-Ping,Liu, Zhao-Jie
, p. 3636 - 3640 (2007/10/03)
Thirteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogues of strobilurins, which contain two pharmacophoric substructures of the methyl (E)-methoxyiminoacetate moiety and 1,3,5-substituted pyrazole ring, were stereoselectively synthesized. It was found that the coupling reaction could give stereoselectively (E:Z ca. 14:1) the key intermediate material (E)-methyl 2-(hydroxyimino)-2-o-tolyl acetate (2). An X-ray crystallographic structure determination was carried out in a representative product. The preliminary bioassays indicated that all of the compounds 1 showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola, and Bipolaris mayclis.
Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides
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Page column 29, (2010/01/30)
Compounds with fungicidal and insecticidal properties having formula wherein X is N or CH; Z is O, S or NR8; A is hydrogen, halo, cyano, (C1-C12)alkyl, or (C1-C12)alkoxy; R1and R8are independently hydrogen or (C1-C4)alkyl; R2is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, heterocyclic, heterocyclic(C1-C4)alkyl or C(R10)═N—OR9; R3is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R4and R5are independently hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, halo, cyano, (C1-C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R6is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, halo, cyano, (C1-C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3-C7)cycloalkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R7is aryl, aralkyl, heterocyclic or heterocyclic(C1-C4)alkyl; R9is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, (C1-C4)alkylcarbonyl, (C1-C4)alkoxycarbonyl, aryl, or aralkyl; and R10is hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C1-C4)alkyl.
Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides
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, (2008/06/13)
Compounds with fungicidal and insecticidal properties having formula STR1 wherein X is N or CH; Z is O, S or NR8 ; A is hydrogen, halo, cyano, (C1 -C12)alkyl, or (C1 -C12)alkoxy; R1 and R8 are independently hydrogen or (C1 -C4)alkyl; R2 is hydrogen, (C1 -C12)alkyl, halo(C1 -C12)alkyl, (C3 -C7)cycloalkyl, halo(C3 -C7)cycloalkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, aryl, aralkyl, heterocyclic, heterocyclic(C1 -C4)alkyl or C(R10)=N--OR9 ; R3 is hydrogen, (C1 -C12)alkyl, halo(C1 -C12)alkyl, (C3 -C7)cycloalkyl, halo(C3 -C7)cycloalkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, aryl, aralkyl, aryl(C3 -C7)cycloalkyl, heterocyclic or heterocyclic(C1 -C4)alkyl; R4 and R5 are independently hydrogen, (C1 -C12)alkyl, halo(C1 -C12)alkyl, (C3 -C7)cycloalkyl, halo(C3 -C7)cycloalkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, halo, cyano, (C1 -C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3 -C7)cycloalkyl, heterocyclic or heterocyclic(C1 -C4)alkyl; R6 is hydrogen, (C1 -C12)alkyl, halo(C1 -C12)alkyl, (C3 -C7)cycloalkyl, halo(C3 -C7)cycloalkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, halo, cyano, (C1 -C4)alkoxycarbonyl, aryl, aralkyl, aryl(C3 -C7)cycloalkyl, heterocyclic or heterocyclic(C1 -C4)alkyl; R7 is aryl, aralkyl, heterocyclic or heterocyclic(C1 -C4)alkyl; R9 is hydrogen, (C1 -C12,)alkyl, halo(C1 -C12)alkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, (C1 -C4)alkylcarbonyl, (C1 -C4)alkoxycarbonyl, aryl, or aralkyl; and R10 is hydrogen, (C1 -C12)alkyl, halo(C1 -C12)alkyl, (C3 -C7)cycloalkyl, halo(C3 -C7)cycloalkyl, (C2 -C8)alkenyl, halo(C2 -C8)alkenyl, (C2 -C8)alkynyl, halo(C2 -C8)alkynyl, aryl, aralkyl, heterocyclic, or heterocyclic(C1 -C4)alkyl.
Aryl and heteroarylcyclopropyl oxime ethers and their use as fungicides and insecticides
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, (2008/06/13)
Compounds with fungicidal and insecticidal properties having formula: ???wherein X is N or CH; Y is O, S, or NR7; A is selected from the group consisting of hydrogen, halo, cyano, (C1-C12)alkyl, and (C1-C12)alkoxy; R1 and R8 are each independently selected from the group consisting of hydrogen, and (C1-C4)alkyl; R2 is selected from the group consisting of hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, heterocyclic, heterocyclic(C1-C4)alkyl, and C(R10)=N-OR9; R3 is selected from the group consisting of aryl, aralkyl, heterocyclic and heterocyclic(C1-C4)alkyl; R4 and R5 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, halo, cyano, and (C1-C4)alkoxycarbonyl; R6 and R7 are each independently selected from the group consisting of hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, (C1-C4)alkoxy(C1-C12)alkyl, halo(C1-C4)alkoxy(C1-C12)alkyl, (C1-C4)alkoxy(C2-C8)alkenyl, and halo(C1-C4)alkoxy(C2-C8)alkenyl; R9 is selected from the group consisting of hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, (C1-C4)alkylcarbonyl, (C1-C4)alkoxycarbonyl, aryl, and aralkyl; and R10 is selected from the group consisting of hydrogen, (C1-C12)alkyl, halo(C1-C12)alkyl, (C3-C7)cycloalkyl, halo(C3-C7)cycloalkyl, (C2-C8)alkenyl, halo(C2-C8)alkenyl, (C2-C8)alkynyl, halo(C2-C8)alkynyl, aryl, aralkyl, heterocyclic, and heterocyclic(C1-C4)alkyl.
