189747-31-7

Basic information

• Product Name: 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one
• Synonyms: 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one;6-chloro-3H,4H-pyriMido[5,4-d][1,3]diazin-4-one
• CAS NO: 189747-31-7
• Molecular Formula: C6H3ClN4O
• Molecular Weight: 182.57
• Mol File: 189747-31-7.mol

Chemical Properties

• Boiling Point: 458.567°C at 760 mmHg
• Flash Point: 231.133°C
• Appearance: /
• Density: 1.872g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.829
• CAS DataBase Reference: 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one(189747-31-7)
• EPA Substance Registry System: 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one(189747-31-7)

Safety Data

• Hazardous Substances Data: 189747-31-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs with diverse therapeutic effects.
Used in Agrochemical Synthesis:
In the agrochemical industry, 6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one is utilized as a precursor in the creation of agrochemicals, helping to develop compounds that can protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one is employed as a versatile precursor in organic synthesis, allowing for the preparation of a wide range of chemical structures that can be applied in various scientific and industrial applications.
Used in Medicinal Research:
6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one is used as a research tool in medicinal chemistry to explore its potential in the treatment of various diseases, given its unique structural features and reactivity.
Used in Chemical Research:
6-Chloropyrimido[5,4-d]pyrimidin-4(3H)-one is utilized in chemical research to study its properties and reactions, contributing to the understanding of heterocyclic chemistry and its implications in material and life sciences.

InChI:InChI=1/C6H3ClN4O/c7-6-8-1-3-4(11-6)5(12)10-2-9-3/h1-2H,(H,9,10,12)

Upstream product

• 14036-06-7 diethoxymethyl acetate 
• 189747-29-3 5-amino-2-chloropyrimidine-4-carboxamide 
• 59950-50-4 ethyl 5-amino-2-chloropyrimidine-4-carboxylate 

Downstream Products

• 189747-43-1 4-[(3-bromophenyl)amino]-6-chloropyrimido[5,4-d]pyrimidine 
• 189747-55-5 4-[(3-methylphenyl)amino]-6-chloropyrimido[5,4-d]pyrimidine 
• 189747-37-3 6-chloro-4-(phenylamino)pyrimido[5,4-d]pyrimidine 
• 189747-34-0 2,8-dichloropyrimido(5,4-d)pyrimidine 

Relevant articles and documents

Tyrosine kinase inhibitors. 12. Synthesis and structure-activity relationships for 6-substituted 4-(phenylamino)pyrimido[5,4-d]pyrimidines designed as inhibitors of the epidermal growth factor receptor

A series of 6-substituted 4-anilinopyrimido[5,4-d]pyrimidines has been prepared and shown to be potent inhibitors of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR). These compounds are structurally related to the pyrido[3,2-d]