Bioorganic and Medicinal Chemistry Letters p. 3187 - 3192 (1999)
Update date:2022-08-02
Topics:
Lau, Cheuk K.
Brideau, Christine
Chan, Chi Chung
Charleson, Stella
Cromlish, Wanda A.
Ethier, Diane
Yves Gauthier, Jacques
Gordon, Robert
Guay, Jocelyne
Kargman, Stacia
Li, Chun-Sing
Prasit, Petpiboon
Riendeau, Denis
Therien, Michel
Visco, Denise M.
Xu, Lijing
A series of 3-heteroaryloxy-4-phenyl-2-(5H)-furanones were prepared and evaluated for their potency and selectivity as COX-2 inhibitors. This led to the identification of L-778,736 as a potent, orally active and selective inhibitor of the COX-2 enzyme.
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Doi:10.1021/jf60158a021
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