190003-75-9

Upstream product

• 74580-95-3 1,2-O-isopropylidene-3-O-mesyl-α-D-xylofuranose 
• 98-88-4 benzoyl chloride 
• 124-63-0 methanesulfonyl chloride 
• 6022-96-4 5-O-benzoyl-α-D-xylofuranose 
• 20031-21-4 1,2-O-isopropylidene-α-D-xylose 
• 532-20-7 D-xylofuranose 
• 5450-26-0 1,2,5,6-di-O-isopropylidene-3-O-methylsulfonyl-α-D-glucofuranose 
• 16848-28-5 1,2-O-isopropylidene-3-O-methanesulfonyl-α-D-glucofuranose 
• 582-52-5 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 

Downstream Products

• 177949-07-4 5-O-benzoyl-1,2-di-O-acetyl-3-O-methanesulfonyl-α/β-D-xylofuranose 
• 219989-61-4 Benzoic acid (2R,3S,4R)-3,4,5-tris-methanesulfonyloxy-tetrahydro-furan-2-ylmethyl ester 
• 122567-97-9 5′-benzoyl-2′,3′-didehydro-3′-deoxythymidine 
• 3056-17-5 stavudin 
• 190003-82-8 1-(5-O-benzoyl-3-O-mesyl-β-D-xylofuranosyl)thymine 
• 190003-79-3 1-(2'-O-acetyl-5'-O-benzoyl-3'-O-methylsulfonyl-β-D-xylofuranosyl)thymine 
• 190003-86-2 2,2'-anhydro-1-(5'-O-benzoyl-3'-O-methylsulfonyl-β-D-lyxofuranosyl)thymine 
• 190003-84-0 1-(5'-O-benzoyl-2',3'-di-O-methylsulfonyl-β-D-xylofuranosyl)thymine 

Relevant academic research and scientific papers

Synthesis and comparative evaluation of two antiviral agents: β-L- Fd4C and β-D-Fd4C

The synthesis of β-D-Fd4C was achieved in a stereoselective fashion from D-xylose. The antiviral activity and cytotoxicity of β-D-Fd4C was compared with that of β-L-Fd4C and 3TC (Lamivudine). Of the three agents compared, β-L-Fd4C was found to be the most potent antiviral agent.

Transformations of β-D-Xylofuranosyl Nucleosides. Synthesis of 3′-Deoxy-2′,3′-didehydrothymidine (D4T)

3′-Deoxy-2′,3′-didehydrothymidine was synthesized through a 10-step procedure starting from D-xylose. The overall yield of the target product was 28%.

Chemical Synthesis of 13C-labelled Monomers for the Solid-Phase and Template Controlled Enzymatic Synthesis of DNA and RNA Oligomers

The preparation of 13C-labelled ribonucleosides starting from -glucose 1 and the corresponding nucleobases 5a-e or 6a-e (N6-benzoyl-adenine, N2-acetyl-guanine, N4-benzoyl-cytosine, uracil and thymine) in 47-66percent overall yield is described.Their subsequent transformation into 5'-O-dimethoxytrityl protected DNA-phosphoramidites and 5'-O-dimethoxytrityl-2'-O-trialkylsilyl protected RNA-phosphor-amidites for the solid phase synthesis of DNA- and RNA-oligomers and to 5'-O-ribo- and deoxyribo-nucleosidetriphosphates for template controlled enzymatic synthesis (polymerase- or reverse transcriptase reaction) has been carried out.